Reactome: A Curated Pathway Database
Found 18900 matches:
'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus
'Eph'ective signaling: forward, reverse and crosstalk
'Genome gating'; polarized intranuclear trafficking of influenza virus RNPs
'Small'-proteoglycan:collagen interactions: keratan sulphate proteoglycan associates with rabbit corneal collagen fibrils at the 'a' and 'c' bands
(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G
(de)MYSTification and INGenuity of tumor suppressors
(IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer
04 and A007-sulfatide antibodies bind to embryonic Schwann cells prior to the appearance of galactocerebroside; regulation of the antigen by axon-Schwann cell signals and cyclic AMP
1,4-benzothiazines as key intermediates in the biosynthesis of red hair pigment pheomelanins
1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase)
1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site
11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus
11-cis-Acyl-CoA:retinol O-acyltransferase activity in the primary culture of chicken Muller cells
11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation
11-Hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase
14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s)
14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction
14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking
15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils
2'-O-methyl modification in mouse piRNAs and its methylase
2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency Is caused by mutations in the HADH2 gene
2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
3' end formation of PIWI-interacting RNAs in vitro
3'-end processing of pre-mRNA in eukaryotes.
3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency
3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.
3-Ketothiolase deficiency
3-Methylglutaconic aciduria type I is caused by mutations in AUH.
3D structure of Syk kinase determined by single-particle electron microscopy
3D structure of the influenza virus polymerase complex: localization of subunit domains
3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region
4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation
5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria
5'-Adenylic acid deaminase. III. Properties and kinetic studies.
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC
5'-nucleotidase: molecular structure and functional aspects
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming
5-hydroxytryptamine (5-HT) receptor ligands
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
5-Methylcytosine DNA demethylation: more than losing a methyl group
5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence
5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex
5-Oxoprolinase deficiency: report of the first human OPLAH mutation
5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH) Missense Changes
53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.
53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis
53BP1, a mediator of the DNA damage checkpoint.
57 varieties: the human cytochromes P450
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species
6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding site and modelling of substrate binding
8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
8p11 myeloproliferative syndrome: a review
8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1
?-Catenin, a Sox2 binding partner, regulates the DNA binding and transcriptional activity of Sox2 in breast cancer cells
?2-Adaptin is functioning in the late endosomal sorting pathway and interacts with ESCRT-I and -III subunits
?TAT1 catalyses microtubule acetylation at clathrin-coated pits
A freeze-fracture paradigm of the mechanism for delivery and insertion of gap junction particles into the plasma membrane
A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones
A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos
A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin
A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression
A 13C nuclear magnetic resonance study of CO2/HCO-3 exchange catalyzed by human carbonic anhydrase I
A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR
A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch
A 7 bp mutation converts a human RNA polymerase II snRNA promoter into an RNA polymerase III promoter
A 92 kDa gelatinase (MMP-9) cleavage site in native type V collagen
A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor
A BBSome subunit links ciliogenesis, microtubule stability, and acetylation
A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases
A bipolar clamp mechanism for activation of Jak-family protein tyrosine kinases
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation
A C-terminal silencing domain in GW182 is essential for miRNA function
A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins
A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma
A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1
A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51)
A case of multiple primary squamous-celled carcinomata in a young man, with spontaneous healing.
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion
A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1
A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases
A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide
A cDNA encoding the calcitonin gene-related peptide type 1 receptor
A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation
A cell biological view of Toll-like receptor function: regulation through compartmentalization
A cell-based reglucosylation assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit
A chemical and enzymological comparison of the common major human erythrocyte carbonic anhydrase II, its minor component, and a new genetic variant, CA II Melbourne (237 Pro leads to His)
A chondrodysplasia family produced by mutations in the diastrophic dysplasia sulfate transporter gene: genotype/phenotype correlations
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor
A cluster of proton/amino acid transporter genes in the human and mouse genomes
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
A collagen-associated Ehrlich chromogen: a pyrrolic cross-link?
A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1
A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s
A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis
A common mutation for mucopolysaccharidosis type I associated with a severe Hurler syndrome phenotype
A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida
A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments
A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization
A comparison of eubacterial and archaeal structure-specific 5'-endonucleases.
A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S
A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes
A comparison of the properties of fructose 1,6-diphosphatase, and the activities of other key enzymes of carbohydrate metabolism, in the livers of embryonic and adult rat, sheep and domestic fowl
A comparison of the properties of two classes, C4A and C4B, of the human complement component C4
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
A compound heterozygote case of type II aldosterone synthase deficiency
A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
A conformational switch in syntaxin during exocytosis: role of munc18
A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96
A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression
A conserved cysteine cluster, essential for transcriptional activity, mediates homodimerization of human metal-responsive transcription factor-1 (MTF-1)
A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
A conserved family of enzymes that phosphorylate inositol hexakisphosphate
A conserved family of prolyl-4-hydroxylases that modify HIF
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
A conserved mechanism for sulfonucleotide reduction
A conserved mechanism of Hedgehog gradient formation by lipid modifications
A conserved phosphatase cascade that regulates nuclear membrane biogenesis
A conserved region in the amino terminus of DNA polymerase delta is involved in proliferating cell nuclear antigen binding
A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
A contractile activity that closes phagosomes in macrophages
A control region in the center of the 5S RNA gene directs specific initiation of transcription: I. The 5' border of the region.
A control region in the center of the 5S RNA gene directs specific initiation of transcription: II. The 3' border of the region.
A controlled vocabulary for pathway entities and events
A cooperative action of the ATP-dependent import motor complex and the inner membrane potential drives mitochondrial preprotein import
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes
A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
A critical review of the origin and control of adrenal androgens
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery
A current review of fatty acid transport proteins (SLC27)
A current view of the mammalian aquaglyceroporins
A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
A cytoplasmic chaperonin that catalyzes beta-actin folding
A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy
A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl alpha3-glucosyltransferase defines a new subtype of congenital disorders of glycosylation
A defined human system that supports bidirectional mismatch-provoked excision
A deletion in the gene for transforming growth factor beta type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma
A deoxynucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease
A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells
A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
A dimerization-dependent mechanism drives RAF catalytic activation
A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis
A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing
A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons
A direct role for GRASP65 as a mitotically regulated Golgi stacking factor
A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
A distinct autosomal recessive disorder of limb development with preaxial brachydactyly, phalangeal duplication, symphalangism and hyperphalangism
A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex
A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice
A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions.
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
A drug targeting only p110? can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT)
A dynein light intermediate chain, D1bLIC, is required for retrograde intraflagellar transport
A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase
A FADD-dependent innate immune mechanism in mammalian cells
A family of candidate taste receptors in human and mouse
A family of fatty acid binding receptors
A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking
A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development
A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
A family of proteins that inhibit signalling through tyrosine kinase receptors
A fast procedure for the detection of defects in Toll-like receptor signaling
A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins
A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis
A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage
A freely diffusible form of Sonic hedgehog mediates long-range signalling
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane
A functional and regulatory network associated with PIP expression in human breast cancer
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response
A functional C5a anaphylatoxin receptor in a teleost species
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development
A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF
A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome
A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity
A G protein-coupled receptor for UDP-glucose
A G protein-coupled receptor responsive to bile acids
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
A gain-of-function mutation in the HIF2A gene in familial erythrocytosis
A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs
A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria
A gene expression signature shared by human mature oocytes and embryonic stem cells
A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic
A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme
A general map of iron metabolism and tissue-specific subnetworks
A general model for the transmembrane proteins of HIV and other retroviruses
A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion
A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
A germline-specific class of small RNAs binds mammalian Piwi proteins
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC
A global map of p53 transcription-factor binding sites in the human genome
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
A hard way to the nucleus
A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
A high association with cone dystrophy in Fundus albipunctatus caused by mutations of the RDH5 gene
A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
A histone H3 lysine 27 demethylase regulates animal posterior development
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
A homolog of Drosophila Notch expressed during mammalian development
A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese
A homozygous CARD9 mutation in a family with susceptibility to fungal infections
A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium
A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
A human cellular model for studying the regulation of glucagon-like peptide-1 secretion
A human gene encoding morphine modulating peptides related to NPFF and FMRFamide
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene
A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility
A human homologue of the Escherichia coli DnaJ heat-shock protein
A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine
A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension
A human opsin-related gene that encodes a retinaldehyde-binding protein
A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase
A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16
A human purine nucleoside phosphorylase deficiency caused by a single base change
A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
A human STX cDNA confers polysialic acid expression in mammalian cells
A human synaptic vesicle monoamine transporter cDNA predicts posttranslational modifications, reveals chromosome 10 gene localization and identifies TaqI RFLPs
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis
A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon
A human transporter protein that mediates the final excretion step for toxic organic cations
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis
A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency
A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria
A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery
A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II
A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
A limited cytoplasmic region of the prolactin receptor critical for signal transduction
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production
A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family
A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
A matrix metalloproteinase expressed on the surface of invasive tumour cells
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
A mechanism for Wnt coreceptor activation
A mechanistic overview of TET-mediated 5-methylcytosine oxidation
A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme
A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells
A membrane proximal domain of the human interleukin-3 receptor beta c subunit that signals DNA synthesis in NIH 3T3 cells specifically binds a complex of Src and Janus family tyrosine kinases and phosphatidylinositol 3-kinase
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
A microRNA component of the p53 tumour suppressor network
A microRNA in a multiple-turnover RNAi enzyme complex
A microRNA polycistron as a potential human oncogene
A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells
A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors
A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42)
A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress
A mitochondrial import receptor for the ADP/ATP carrier
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases
A model for interstitial collagen catabolism by mammalian collagenases
A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis
A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm
A module of negative feedback regulators defines growth factor signaling
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion
A molecular determinant for submillisecond desensitization in glutamate receptors
A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
A molecular perspective of CTLA-4 function
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor
A motility in the eukaryotic flagellum unrelated to flagellar beating
A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis
A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
A mouse speciation gene encodes a meiotic histone H3 methyltransferase
A multidrug resistance transporter from human MCF-7 breast cancer cells
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo
A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis
A multinuclear copper(I) cluster forms the dimerization interface in copper-loaded human copper chaperone for superoxide dismutase
A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling
A mutant form of PTEN linked to autism
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration
A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin
A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity
A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness
A mutation in the gene of a glycolipid-binding protein (GM2 activator) that causes GM2-gangliosidosis variant AB
A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity
A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)
A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic
A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair.
A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin
A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake
A network model for the organization of type IV collagen molecules in basement membranes
A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin
A new biochemical subtype of the Sanfilippo syndrome: characterization of the storage material in cultured fibroblasts of Sanfilippo C patients
A new class of membrane-bound chemokine with a CX3C motif
A new compound heterozygous mutation (W17X, 436 + 5G --> T) in the cytochrome P450c17 gene causes 17 alpha-hydroxylase/17,20-lyase deficiency
A new concept for energy coupling in oxidative phosphorylation based on a
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia
A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases
A new human hereditary amyloidosis: the result of a stop-codon mutation in the apolipoprotein AII gene
A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF
A new job for ancient extracellular matrix proteins: Hemicentins stabilize cleavage furrows
A new look at blood coagulation factor V
A new look at the renin-angiotensin system--focusing on the vascular system
A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus
A new map of glycosaminoglycan and C3b binding sites on factor H
A new mechanism for the regulation of Gab1 recruitment to the plasma membrane
A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription
A new model for how O6-methylguanine-DNA methyltransferase binds DNA
A new multiple congenital anomaly, mental retardation syndrome with preaxial brachydactyly, hyperphalangism, deafness and orodental anomalies
A new nuclear component of the Wnt signalling pathway
A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
A new role for the mitotic RAD21/SCC1 cohesin in meiotic chromosome cohesion and segregation in the mouse
A new secreted protein that binds to Wnt proteins and inhibits their activities
A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility
A new subunit of the cyclic nucleotide-gated cation channel in retinal rods
A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis
A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling
A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
A nomenclature for signal regulatory protein family members
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo
A novel accessory subunit for vacuolar H(+)-ATPase from chromaffin granules
A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line
A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
A novel and highly conserved collagen (pro(alpha)1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP
A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets
A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation
A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase
A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation
A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer
A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2
A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization
A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration
A novel class of RanGTP binding proteins
A novel class of small RNAs bind to MILI protein in mouse testes
A novel class of small RNAs in mouse spermatogenic cells
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini
A novel compound heterozygous mutation in the RDH5 gene in a patient with fundus albipunctatus
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder
A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice
A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5
A novel disorder caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency
A novel eukaryotic factor for cytosolic Fe-S cluster assembly
A novel factor binding to the glucose response elements of liver pyruvate kinase and fatty acid synthase genes
A novel family of mammalian taste receptors
A novel family of membrane-bound E3 ubiquitin ligases
A novel fluor in insoluble collagen: a crosslinking moiety in collagen molecule
A novel form of the G protein beta subunit Gbeta5 is specifically expressed in the vertebrate retina.
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling
A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia
A novel gain-of-function IKBA mutation underlies ectodermal dysplasia with immunodeficiency and polyendocrinopathy
A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis
A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS
A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism
A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
A novel human Cl(-) channel family related to Drosophila flightless locus
A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid
A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
A novel human opsin in the inner retina
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
A novel human phosphotransferase highly specific for adenosine
A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer
A novel influenza A virus mitochondrial protein that induces cell death
A novel inhibitor of beta-glucuronidase: L-aspartic acid
A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling
A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding
A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels
A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages
A novel mechanism for GABA synthesis and packaging into synaptic vesicles
A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion.
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
A novel method to monitor insulin-stimulated GTP-loading of Rab11a in cardiomyocytes
A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally
A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type
A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production
A novel molecular mechanism to explain biotin-unresponsive holocarboxylase synthetase deficiency
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition
A novel mutation in NFKBIA/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42
A novel nuclear export signal in Smad1 is essential for its signaling activity
A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer
A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
A novel partner for the GTP-bound forms of rho and rac
A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3
A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia
A novel point mutation in P450c17 (CYP17) causing combined 17alpha-hydroxylase/17,20-lyase deficiency
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened
A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and disease
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2)
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
A novel quality control compartment derived from the endoplasmic reticulum
A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis
A novel role for XIAP in copper homeostasis through regulation of MURR1
A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence
A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells
A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein
A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene
A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31
A novel splice variant of human gene NPL, mainly expressed in human liver, kidney and peripheral blood leukocyte
A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory
A Novel Strain of Clostridium botulinum That Produces Type B and Type H Botulinum Toxins
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice
A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription
A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
A novel WD repeat protein component of the methylosome binds Sm proteins
A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
A nucleoprotein complex mediates the integration of retroviral DNA
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA
A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein
A palmitoylation switch mechanism regulates Rac1 function and membrane organization
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression
A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor
A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells
A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO
A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors
A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase
A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation
A point mutation in the coding sequence of the beta-hexosaminidase alpha gene results in defective processing of the enzyme protein in an unusual GM2-gangliosidosis variant
A polymorphism in the upstream regulatory region of the interleukin-1? gene confers differential binding by transcription factors of the AP-1 family
A possible genetic defect in 25-hydroxylation as a cause of rickets
A potential role for periplasmic superoxide dismutase in blocking the penetration of external superoxide into the cytosol of Gram-negative bacteria
A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
A previously unidentified host protein protects retroviral DNA from autointegration
A previously unidentified host protein protects retroviral DNA from autointegration
A prolactin-releasing peptide in the brain
A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.
A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily
A proposed role for the Azotobacter vinelandii NfuA protein as an intermediate iron-sulfur cluster carrier
A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway
A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
A protein cofactor of lecithin:cholesterol acyltransferase
A protein interaction framework for human mRNA degradation
A protein interaction network for pluripotency of embryonic stem cells
A protein tyrosine kinase in the interferon alpha/beta signaling pathway
A proteomic analysis of human cilia: identification of novel components
A proteomic study of SUMO-2 target proteins
A pulse radiolysis investigation of the oxidation of the melanin precursors 3,4-dihydroxyphenylalanine (dopa) and the cysteinyldopas
A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation
A quantitative model of human DNA base excision repair. I. Mechanistic insights
A quantitative study of the interactions of Bacillus anthracis edema factor and lethal factor with activated protective antigen
A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis
A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport
A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
A rapid screening method to detect autosomal-dominant ectodermal dysplasia with immune deficiency syndrome
A Rare Disease in Two Brothers
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults
A reassessment of the MAdCAM-1 structure and its role in integrin recognition
A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP
A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses
A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations
A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia
A refined structure of human aquaporin-1
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130
A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state
A regulated interaction between alpha5beta1 integrin and osteopontin
A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation
A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination.
A review of hedgehog signaling in cranial bone development
A review of the molecular genetics of the human alpha-globin gene cluster
A review of the pharmacokinetics of abacavir
A Review of Trimethylaminuria: (Fish Odor Syndrome)
A revised picture of the E2F transcriptional network and RB function.
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
A road map for those who don't know JAK-STAT
A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160
A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway
A role for C/EBPbeta in regulating peroxisome proliferator-activated receptor gamma activity during adipogenesis in 3T3-L1 preadipocytes
A role for calnexin (IP90) in the assembly of class II MHC molecules
A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum
A role for DNA polymerase ? in promoting replication through oxidative DNA lesion, thymine glycol, in human cells
A role for dystroglycan in basement membrane assembly
A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering
A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
A role for Groucho tetramerization in transcriptional repression
A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
A role for human Dicer in pre-RISC loading of siRNAs
A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release
A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis
A role for LEDGF/p75 in targeting HIV DNA integration
A role for MLH3 in hereditary nonpolyposis colorectal cancer
A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity
A role for PCNA ubiquitination in immunoglobulin hypermutation
A role for Plk1 phosphorylation of NudC in cytokinesis
A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis
A role for small RNAs in DNA double-strand break repair
A role for Src in signal relay by the platelet-derived growth factor alpha receptor
A role for syndecan-1 in coupling fascin spike formation by thrombospondin-1
A role for TFIIH in controlling the activity of early RNA polymerase II elongation complexes.
A role for the basic patch and the C terminus of RanGTP in regulating the dynamic interactions with importin beta, CRM1 and RanBP1
A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin
A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
A role for the P-body component GW182 in microRNA function
A role for the thiol isomerase protein ERP5 in platelet function
A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay
A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity
A role of apolipoprotein D in triglyceride metabolism
A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses
A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
A roller coaster ride with the mitotic cyclins
A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
A second calcineurin binding site on the NFAT regulatory domain
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins
A second human calcitonin/CGRP gene
A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders
A second mammalian N-myristoyltransferase
A second origin of DNA plus-strand synthesis is required for optimal Human Immunodeficiency Virus replication
A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase
A self-scaffolding model for G protein signaling
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology
A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip
A short chain (pro)collagen from aged endochondral chondrocytes. Biochemical characterization
A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein
A short sequence in the N-terminal region is required for the trimerization of type XIII collagen and is conserved in other collagenous transmembrane proteins
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor
A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance
A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif)
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction
A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
A single copy of apolipoprotein B-48 is present on the human chylomicron remnant
A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis
A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins
A single mammalian mitochondrial translation initiation factor functionally replaces two bacterial factors
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription
A single Sec61-complex functions as a protein-conducting channel
A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation
A six-armed oligomer isolated from cell surface fibronectin preparations
A Smad transcriptional corepressor
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction
A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion
A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity
A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity
A specific growth hormone-binding protein in human plasma: initial characterization
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions
A specific transcription factor that can bind either the 5S RNA gene or 5S RNA
A sperm ion channel required for sperm motility and male fertility
A spring-loaded mechanism for the conformational change of influenza hemagglutinin
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
A stable complex between integrase and viral DNA ends mediates human immunodeficiency virus integration in vitro
A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements
A standardized kinesin nomenclature
A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol
A stimulatory role for cGMP-dependent protein kinase in platelet activation
A stoichiometric complex of neurexins and dystroglycan in brain
A stop-codon mutation in the BRI gene associated with familial British dementia
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
A structural basis for mutational inactivation of the tumour suppressor Smad4
A structural basis for the unique binding features of the human vitamin D-binding protein
A structural change in the kinesin motor protein that drives motility
A structural model for the membrane-integral domain of succinate: quinone
A structural perspective on copper uptake in eukaryotes
A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors
A structural view of the COPII vesicle coat
A structural-dynamical characterization of human Cox17
A study of ornithine, citrulline and arginine synthesis in growing chicks
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
A subunit of mammalian signal peptidase is homologous to yeast SEC11 protein
A sulfilimine bond identified in collagen IV
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis
A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice
A syndrome with congenital neutropenia and mutations in G6PC3
A synopsis of the unconjugated acidic transamination metabolites of phenylalanine in phenylketonuria
A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition
A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
A telomerase component is defective in the human disease dyskeratosis congenita
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.
A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients
A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins
A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses
A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome
A three-step purification of manganese superoxide dismutase from human liver on both large and small scales
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
A Toll-like receptor recognizes bacterial DNA
A transcription factor regulatory circuit in differentiated pancreatic cells
A transcription factor response element for gene expression during circadian night
A transcriptional partner for MAD proteins in TGF-beta signalling
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule
A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly
A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain
A truncated form of CKbeta8-1 is a potent agonist for human formyl peptide-receptor-like 1 receptor
A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway
A type X collagen mutation causes Schmid metaphyseal chondrodysplasia
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway
A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage
A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination
A ubiquitously expressed human hexacoordinate hemoglobin
A unified model for apical caspase activation
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities
A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function
A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription
A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q
A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex
A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase
A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase
A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein
A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR
A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF
A UPF3-mediated regulatory switch that maintains RNA surveillance
A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3
A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions
A yeast chromosomal origin of DNA replication defined by multiple functional elements
A yeast gene required for DNA replication encodes a protein with homology to DNA helicases.
A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells
A2E, a byproduct of the visual cycle
AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes.
ABC transporters and cholesterol metabolism
ABC transporters in cellular lipid trafficking
ABC transporters: the power to change
ABC50 promotes translation initiation in mammalian cells
ABCA1-induced cell surface binding sites for ApoA-I
ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter
ABCA3 gene mutations in newborns with fatal surfactant deficiency
ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells
ABCA6, a novel a subclass ABC transporter
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
ABCG1 redistributes cellular cholesterol to domains removable by high density lipoproteins but not by lipid-depleted lipoproteins
Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine
ABCG4: a novel human white family ABC-transporter expressed in the brain and eye
ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion
Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway
Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression
Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability
Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice
Abnormalities of the APC/beta-catenin pathway in endometrial cancer
Abortive initiation by RNA polymerase II in vitro at the adenovirus 2 major late promoter.
Abortive initiation by Saccharomyces cerevisiae RNA polymerase III.
Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.
Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides
Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis
Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
Absorption of chlorophyll phytol in normal man and in patients with Refsum's disease
Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1
Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells
Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor
Accessing naïve human pluripotency
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
Accumulation of nonphosphorylated beta-catenin and c-myc in primary and uremic secondary hyperparathyroid tumors
Accuracy of DNA methylation pattern preservation by the Dnmt1 methyltransferase
Accurate cleavage and polyadenylation of exogenous RNA substrate.
Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
Acetylation and deacetylation of non-histone proteins
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
Acetylation of beta-catenin by CREB-binding protein (CBP)
Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription.
Acetylcholine regulates ghrelin secretion in humans
Acetylpolyamine amidohydrolase from Mycoplana ramosa: gene cloning and characterization of the metal-substituted enzyme
Achievements and challenges of sialic acid research
Achondrogenesis type IB is caused by mutations in the diastrophic dysplasia sulphate transporter gene
Achondroplasia is defined by recurrent G380R mutations of FGFR3
Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel
Acid-sensing ion channels (ASICs): pharmacology and implication in pain
Acidosis, acid-sensing ion channels, and neuronal cell death
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
Aconitase polymorphism in man
Acquired and inherited disorders of cobalamin and folate in children
Acquisition of SOX transcription factor specificity through protein-protein interaction, modulation of Wnt signalling and post-translational modification
Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction
Actin dynamics control SRF activity by regulation of its coactivator MAL
Actin-binding and dimerization domains of HeLa cell filamin
Action potentials and insulin secretion: new insights into the role of Kv channels
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
Activated protein C
Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms
Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator
Activating and inhibitory functions of DAP12
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis
Activating transcription factor 4 is translationally regulated by hypoxic stress
Activation and association of Stat3 with Src in v-Src-transformed cell lines
Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site
Activation and detoxication of aflatoxin B1
Activation and detoxication of aflatoxin B1
Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein.
Activation and signaling of the p38 MAP kinase pathway
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells
Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
Activation domains from both monomers contribute to transcriptional stimulation by sterol regulatory element-binding protein dimers
Activation kinetics of single P2X receptors
Activation mechanism and steady state kinetics of Bruton's tyrosine kinase
Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat
Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas
Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2
Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells
Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro
Activation of C1r by proteolytic cleavage
Activation of caspases-8 and -10 by FLIP(L)
Activation of chicken alternative complement pathway by fowlpox virus-infected cells
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
Activation of downstream signals by the long form of the leptin receptor
Activation of EGF receptor kinase by L1-mediated homophilic cell interactions
Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
Activation of epidermal growth factor receptor by epidermal growth factor
Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2
Activation of factor VIII and mechanisms of cofactor action
Activation of factor VIII and mechanisms of cofactor action
Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets
Activation of FAK and Src are receptor-proximal events required for netrin signaling
Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII
Activation of FGF receptors by mutations in the transmembrane domain
Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation
Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces.
Activation of human factor X (Stuart factor) by a protease from Russell's viper venom
Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor)
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage
Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1
Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase
Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine
Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways
Activation of human progelatinase A by collagenase and matrilysin: activation of procollagenase by matrilysin
Activation of human prolegumain by cleavage at a C-terminal asparagine residue
Activation of IkappaB kinase beta by protein kinase C isoforms
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
Activation of initiator caspases through a stable dimeric intermediate
Activation of innate immune antiviral responses by Nod2
Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor
Activation of interstitial collagenase, MMP-1, by Staphylococcus aureus cells having surface-bound plasmin: a novel role of plasminogen receptors of bacteria
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130
Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network
Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
Activation of neutrophil collagenase by cathepsin G
Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex
Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Activation of orphan receptors by the hormone relaxin
Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation
Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis.
Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation
Activation of phospholipase C isozymes by G protein beta gamma subunits
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate
Activation of phospholipase Cgamma2 by tyrosine phosphorylation
Activation of plasminogen by pro-urokinase. I. Mechanism.
Activation of platelet-activating factor receptor-coupled G alpha q leads to stimulation of Src and focal adhesion kinase via two separate pathways in human umbilical vein endothelial cells
Activation of PPARgamma coactivator-1 through transcription factor docking
Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II
Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13)
Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis
Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells
Activation of Raf as a result of recruitment to the plasma membrane
Activation of Raf-1 by 14-3-3 proteins
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c
Activation of receptor-associated tyrosine kinase JAK2 by prolactin
Activation of Rho kinase isoforms in lung endothelial cells during inflammation
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a
Activation of signalling by the activin receptor complex
Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains
Activation of STAT6 by STING is critical for antiviral innate immunity
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
Activation of the 92 kDa type IV collagenase by tissue kallikrein
Activation of the alternative complement pathway
Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1
Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.\nActivation of the ATM kinase by ionizing radiation and phosphorylation of p53.\n
Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins
Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure
Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine
Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin
Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'
Activation of the interleukin 2 receptor: a possible role for tyrosine phosphatases
Activation of the lectin complement pathway by H-ficolin (Hakata antigen)
Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers
Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
Activation of the NF-kappaB pathway by caspase 8 and its homologs
Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases
Activation of the prostaglandin FP receptor in human granulosa cells
Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression
Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells
Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
Activation of the STAT3/acute phase response factor transcription factor by interleukin-5
Activation of the TLR3 pathway regulates IFNbeta production in chickens
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements
Activation of the WAVE complex by coincident signals controls actin assembly
Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box
Activation of Toll-like receptors inhibits herpes simplex virus-1 infection of human neuronal cells
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein
Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides
Activation of Trk neurotrophin receptors in the absence of neurotrophins
Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins
Activation of type IV procollagenases by human tumor-associated trypsin-2
Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde
Activation of Wnt and Myc signaling in hepatoblastoma
Activation parameters for the carbonic anhydrase II-catalyzed hydration of CO2
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
Active establishment of centromeric CENP-A chromatin by RSF complex
Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly
Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria
Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design
Active site remodelling accompanies thioester bond formation in the SUMO E1
Active site residues of cyclophilin A are crucial for its signaling activity via CD147
Active sugar transport in health and disease
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain
Active Wnt proteins are secreted on exosomes
Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase
Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells
Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation
Activin B can signal through both ALK4 and ALK7 in gonadotrope cells
Activin isoforms signal through type I receptor serine/threonine kinase ALK7
Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis
Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression
Activin-binding proteins in human serum and follicular fluid
Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
Activity of alpha- and theta-defensins against primary isolates of HIV-1
Activity of matrix metalloproteinase-9 against native collagen types I and III
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease
Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling
Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells
Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling
Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2
Acyl-CoA:lysophospholipid acyltransferases
Acyl-coenzyme A synthetases in metabolic control
Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271)
ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists
ADAP-ting TCR signaling to integrins
Adapters in lymphocyte signaling
Adapters in the organization of mast cell signaling
Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature
Adaptor protein Lnk associates with Tyr(568) in c-Kit
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells
Adaptors and molecular scaffolds in immune cell signaling
Adaptors as central mediators of signal transduction in immune cells
ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
Addition of quantitative 3-hydroxy-octadecanoic acid to the stable isotope gas chromatography-mass spectrometry method for measuring 3-hydroxy fatty acids
Addition of truncated oligosaccharides to influenza virus hemagglutinin results in its temperature-conditional cell-surface expression
Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen
Adenosine A(2A) receptor mRNA regulation by nerve growth factor is TrkA-, Src-, and Ras-dependent via extracellular regulated kinase and stress-activated protein kinase/c-Jun NH(2)-terminal kinase
Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin
Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets
Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne muscular dystrophic serum aberrant adenylate kinase
Adenylate deaminase. Kinetic and binding studies on the rabbit muscle enzyme
Adenylate kinases in man: evidence for a third locus
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
Adherens junctions
Adhesion mechanisms in platelet function
Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation
Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets
Adhesion-modulating/matricellular ECM protein families: a structural, functional and evolutionary appraisal
Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide
Adipocyte differentiation from the inside out
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
Adipocytes recognize and degrade oxidized low density lipoprotein through CD36
Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+
ADP and platelets: the end of the beginning
ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways
ADP-ribosylation factor 1 transiently activates high-affinity adaptor protein complex AP-1 binding sites on Golgi membranes
ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products
ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products
Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors
Adrenodoxin: structure, stability, and electron transfer properties
Adrenoleukodystrophy gene: unexpected homology to a protein involved in peroxisome biogenesis
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma
Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells
Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology
Advances in avian immunology--prospects for disease control: a review
Advances in collagen cross-link analysis
Advances in tenascin-C biology
Advances in the understanding of cobalamin assimilation and metabolism
AES/GRG5: more than just a dominant-negative TLE/GRG family member
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction
Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme
Affinity purification of mammalian RNA polymerase I. Identification of an associated kinase.
Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction
Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase
Aflatoxin B1-induced DNA damage and its repair
Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention
Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography
Age related changes in the reducible cross-links of collagen
Age-dependent changes in eumelanin composition in hairs of various ethnic origins
Age-related variations in hydroxylation of lysine and proline in collagen
Ageing and endocrine cells of human duodenum
Aggrecanase and aggrecan degradation in osteoarthritis: a review
Aggregation states of mitochondrial malate dehydrogenase
Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver
Agmatine: at the crossroads of the arginine pathways
Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence
Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells
Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor
Agonist occupancy is essential for forward trafficking of AMPA receptors
Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
Agrin acts via a MuSK receptor complex
Agrin binding to alpha-dystroglycan. Domains of agrin necessary to induce acetylcholine receptor clustering are overlapping but not identical to the alpha-dystroglycan-binding region
Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation
Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain
Agrin binds to the nerve-muscle basal lamina via laminin
Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma
Agrin is a heparan sulfate proteoglycan
Agrin isoforms with distinct amino termini: differential expression, localization, and function
Agrin/MuSK signaling: willing and Abl
Agrin: an extracellular matrix heparan sulfate proteoglycan involved in cell interactions and synaptogenesis
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
AIP4/Itch regulates Notch receptor degradation in the absence of ligand
Akt phosphorylates and regulates the orphan nuclear receptor Nur77
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription
AKT/PKB signaling: navigating downstream
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
ALCAM regulates mediolateral retinotopic mapping in the superior colliculus
Alcohol dehydrogenases, aldehyde dehydrogenases, and related enzymes
Aldehyde dehydrogenase, a diphosphopyridine nucleotide-linked enzyme
Aldo-keto reductases and bioactivation/detoxication
Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels
Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans
Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands
Aldose reductase, still a compelling target for diabetic neuropathy
Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts
ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg
Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation
ALG6-CDG in South Africa: Genotype-Phenotype Description of Five Novel Patients
Aliskiren displays long-lasting interactions with human renin
Aliskiren versus ramipril in hypertension
ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse
Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes
Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide
Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks
Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism
All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
All purpose Sox: The many roles of Sox proteins in gene expression
All Tcf HMG box transcription factors interact with Groucho-related co-repressors
All three chains of 1 alpha 2 alpha 3 alpha collagen from hyaline cartilage resist human collagenase
All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
Allelic variation in TLR4 is linked to susceptibility to Salmonella enterica serovar Typhimurium infection in chickens
Allelism, non-allelism, and genetic compounds among the mucopolysaccharidoses
Allosteric activation of latent p53 tetramers
Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance
alpha 1(Xx) collagen, a new member of the collagen subfamily, fibril-associated collagens with interrupted triple helices
alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens
Alpha 2 beta 1 integrin mediates dermal fibroblast attachment to type VII collagen via a 158-amino-acid segment of the NC1 domain
Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells
Alpha 2-macroglobulin
Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes
Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina
Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin
alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly
Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4
alpha-Glucosidase deficiency in generalized glycogen-storage disease (Pompe's disease)
Alpha-glycan phosphorylases - chemical and physical basis of catalysis and regulation
alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype
Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells
alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells
Alteration of clathrin light chain expression by transfection and gene disruption
Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients
Alteration of enzyme specificity by computational loop remodeling and design
Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia
Alterations of the IKBKG locus and diseases: an update and a report of 13 novel mutations
Altered aquaporin 9 expression and localization in human hepatocellular carcinoma
Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation
Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype
Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms
Alternate signalling pathways from the interleukin-2 receptor
Alternating hemiplegia of childhood or familial hemiplegic migraine? A novel ATP1A2 mutation
Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression
Alternative outcomes in assembly of promoter complexes: the roles of TBP and a flexible linker in placing TFIIIB on tRNA genes
Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway
Alternative pathway therapy for urea cycle disorders: twenty years later
Alternative pathways for angiotensin II generation in the cardiovascular system
Alternative RNA splicing that determines agrin activity regulates binding to heparin and alpha-dystroglycan
Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes
Alternative splicing controls the mechanisms of FAK autophosphorylation
Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity
Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor
Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion
Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action
Alternative Wnt pathways and receptors
Amiloride-sensitive Na channels
Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells
Amino acid sequence of human beta-factor XIIa
Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA
Amino acid sequence of human liver cathepsin B
Amino acid sequence of human prothrombin fragments 1 and 2
Amino acid sequence of human von Willebrand factor
Amino acid sequence of the a subunit of human factor XIII
Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments
Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor)
Amino acid sequences of the human kidney cathepsins H and L
Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.
Amino acid transport across mammalian intestinal and renal epithelia
Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging
Amino- and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions
Amino-acid sequence of human alpha 2-antiplasmin
Aminoacyl tRNA synthetases and their connections to disease
Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology
Ammonium homeostasis and human Rhesus glycoproteins
Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia
Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells
AMP (dAMP) kinase from human erythrocytes
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
AMP-activated protein kinase inhibits TREK channels
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
AMPA receptor-mediated excitotoxicity in human NT2-N neurons results from loss of intracellular Ca2+ homeostasis following marked elevation of intracellular Na+
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor
AMPK phosphorylation of raptor mediates a metabolic checkpoint
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
Amplification and kinetics of the activation steps in phototransduction
Amplification of a gene encoding a p53-associated protein in human sarcomas
Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate
Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1
Amyloid accomplices and enforcers
Amyloid beta-protein assembly and Alzheimer disease
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform
Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis
Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells
Amyloid Oligomer Structures and Toxicity
Amyloid P component. A critical review
Amyloidosis: new strategies for treatment
An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors
An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
An actin nucleation mechanism mediated by Bni1 and profilin
An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors
An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis
An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein
An alternative branch of the nonsense-mediated decay pathway
An alternative insert of three amino acids is incorporated into collagen XIV in a developmentally regulated fashion
An alternative pathway mediates the mouse and human cone visual cycle
An alternative pathway mediates the mouse and human cone visual cycle
An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure
An analysis of the role of neuraminidase in the receptor-binding activity of influenza B virus: the inhibitory effect of Zanamivir on haemadsorption
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes
An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth
An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis
An AP-1 site is involved in the NGF induction of IL-1 alpha in PC12 cells
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium
An asparagine-phenylalanine substitution accounts for catalytic differences between hGSTM3-3 and other human class mu glutathione S-transferases
An assay for arginase in chicken kidney
An assay for complement factor B in species at different levels of evolution
An assay for measuring the mannan-binding lectin pathway of complement activation in chickens
An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex
An atomic-level mechanism for activation of the kinesin molecular motors
An ATP-dependent succinic thiokinase in birds and its relation to ketone-body utilization
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice
An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins
An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions
An endothelial receptor for oxidized low-density lipoprotein
An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
An enzyme-linked immunosorbent assay for human cathepsin X, a potential new inflammatory marker
An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
An essential role for p300/CBP in the cellular response to hypoxia
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane
An estimate of the mean length of collagen fibrils in rat tail-tendon as a function of age
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators
An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK
An evolving view of the eukaryotic oligosaccharyltransferase
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)
An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.
An in vitro nuclear disassembly system reveals a role for the RanGTPase system and microtubule-dependent steps in nuclear envelope breakdown
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways
An inducible transcription factor activates expression of human immunodeficiency virus in T cells
An influenza virus containing nine different RNA segments
An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor
An integrated genomic analysis of human glioblastoma multiforme
An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1
An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase
An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells
An introduction to TRP channels
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing
An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria
An Italian family with autosomal recessive inclusion-body myopathy and mutations in the GNE gene
An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling
An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
An obligatory role of mind bomb-1 in notch signaling of mammalian development
An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
An overview of sphingolipid metabolism: from synthesis to breakdown
An overview of the Notch signalling pathway
An overview of Y-Family DNA polymerases and a case study of human DNA polymerase ?
An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress
An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein
An updated overview on Wnt signaling pathways: a prelude for more
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor
Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock
Analysis and update of the human solute carrier (SLC) gene superfamily
Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme
Analysis of binding sites on complement factor I that are required for its activity
Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer
Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms
Analysis of CYP7B1 in non-consanguineous cases of hereditary spastic paraplegia
Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates
Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand
Analysis of dolichol in human tissues by high pressure liquid chromatography
Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor
Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
Analysis of gap junction assembly using mutated connexins detected in Charcot-Marie-Tooth X-linked disease
Analysis of Gas6 in human platelets and plasma
Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells
Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets
Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3
Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation
Analysis of heat shock element recognition by saturation mutagenesis of the human HSP70.1 gene promoter
Analysis of heparin, alpha-dystroglycan and sulfatide binding to the G domain of the laminin alpha1 chain by site-directed mutagenesis
Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members
Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association
Analysis of multiple mutations in the hALG6 gene in a patient with congenital disorder of glycosylation Ic
Analysis of mutant Moloney murine leukemia viruses containing linker insertion mutations in the 3' region of pol
Analysis of neurocan structures interacting with the neural cell adhesion molecule N-CAM
Analysis of nucleocytoplasmic shuttling of NF kappa B proteins in human leukocytes
Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress
Analysis of phosphorylation sites on focal adhesion kinase using nanospray liquid chromatography/multiple reaction monitoring mass spectrometry
Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase
Analysis of proteins binding to the ITAM motif of the beta-subunit of the high-affinity receptor for IgE (FcepsilonRI)
Analysis of proteoglycan expression in developing chicken brain: characterization of a heparan sulfate proteoglycan that interacts with the neural cell adhesion molecule
Analysis of replication protein A (RPA) in human spermatogenesis
Analysis of RNA chain elongation and termination by Saccharomyces cerevisiae RNA polymerase III.
Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores
Analysis of small RNA-guided endonuclease activity in endogenous Piwi protein complexes from mouse testes
Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC
Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity
Analysis of the excision step in human DNA mismatch repair
Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus
Analysis of the human sperm proteome
Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly
Analysis of the interactions between properdin, the third component of complement (C3), and its physiological activation products
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
Analysis of the open region of RNA polymerase II transcription complexes in the early phase of elongation.
Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B
Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
Anaphylatoxins: their role in bacterial infection and inflammation
Ancestral organization of the MHC revealed in the amphibian Xenopus
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
Ancillary subunits associated with voltage-dependent K+ channels
Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
Angiomotin-like proteins associate with and negatively regulate YAP1
Angiopoietin and Tie signaling pathways in vascular development
Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
Angiopoietins 3 and 4: diverging gene counterparts in mice and humans
Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE
Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition
Angiotensin II generation by mast cell alpha- and beta-chymases
Angiotensin-converting enzyme in pericardial fluid: comparative study with serum activity
Animal models of retinal disease
Anion carriers in fatty acid-mediated physiological uncoupling
Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus
Anion inhibition of CO2 hydration catalyzed by human carbonic anhydrase II. Mechanistic implications
Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
Annexin A2 system in human biology: cell surface and beyond
Anoctamins are a family of Ca2+ activated Cl- channels
Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene
Another look at collagen V and XI molecules
Another mutation that results in the substitution of an unpaired cysteine residue in the extracellular domain of FGFR3 in thanatophoric dysplasia type I
Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse
Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
Anthrax protective antigen forms oligomers during intoxication of mammalian cells
Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process
Anthrax toxin: receptor binding, internalization, pore formation, and translocation
Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases
Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin
Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation
Antibodies to the human gamma 2 subunit of the gamma-aminobutyric acidA/benzodiazepine receptor
Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
Antibody-independent activation of the classical complement pathway by cytomegalovirus-infected fibroblasts
Anticancer activities of histone deacetylase inhibitors
Anticoagulant and antithrombotic properties of platelet protease nexin-1
Antigen loading of MHC class I molecules in the endocytic tract
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions
Antigen processing and presentation by the class I major histocompatibility complex
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies
Antigen processing and presentation: TAPping into ABC transporters
Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1
Antigenic analysis of the major human phosphoglucomutase isozymes: PGM1, PGM2, PGM3 and PGM4
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Antisense co-suppression of G(alpha)(q) and G(alpha)(11) demonstrates that both isoforms mediate M(3)-receptor-activated Ca(2+) signalling in intact epithelial cells
Antiviral signaling through pattern recognition receptors
Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression
AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate
AP endonuclease-independent DNA base excision repair in human cells
AP-1 function and regulation
AP-1 subunits: quarrel and harmony among siblings
AP-1--Introductory remarks
AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box
Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand
Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome
Apical GLUT2: a major pathway of intestinal sugar absorption
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization
Apo cytochrome c inhibits caspases by preventing apoptosome formation
Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment
APOBEC3G incorporation into human immunodeficiency virus type 1 particles
Apocytochrome c requires the TOM complex for translocation across the mitochondrial outer membrane
Apolipoprotein A-II is catabolized in the kidney as a function of its plasma concentration
Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging
Apolipoprotein E, amyloid, and Alzheimer disease
Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake
Apoptosis and disease: a life or death decision
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis
Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad
Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif
Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis.
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53
Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling
Applications for ROCK kinase inhibition
Approaches to the superior calix: renal displacement technique and review of options
APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl
Aquaporin expression in normal human kidney and in renal disease
Aquaporin-1 and HCO3(-)-Cl- transporter-mediated transport of CO2 across the human erythrocyte membrane
Aquaporin-1, nothing but a water channel
Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
Aquaporin-3 water channel localization and regulation in rat kidney
Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways
Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat
Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
Aquaporins in the kidney: from molecules to medicine
Aquaporins: highways for cells to recycle water with the outside world
Aquaporins: translating bench research to human disease
Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids
Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)
Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase
Architecture and function of IFT complex proteins in ciliogenesis
Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex
Architecture of ribonucleoprotein complexes in influenza A virus particles
Architecture of the human origin recognition complex
Architecture of the large subunit of the mammalian mitochondrial ribosome
Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage.
Architecture of the yeast origin recognition complex bound to origins of DNA replication
Are GAD65 and GAD67 associated with specific pools of GABA in brain?
ARE-mRNA degradation requires the 5'-3' decay pathway
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome
ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
ARF1 regulates Nef-induced CD4 degradation
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma
ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat
Arg encodes a widely expressed 145 kDa protein-tyrosine kinase
Arg tyrosine kinase is involved in homologous recombinational DNA repair
Arginase, ornithine decarboxylase and S-adenosylmethionine decarboxylase in chicken brain and retina
Arginine methylation an emerging regulator of protein function
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable
Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO
Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans
Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression
Argonaute proteins couple chromatin silencing to alternative splicing
Argonaute proteins: mediators of RNA silencing
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
Argonaute2 is the catalytic engine of mammalian RNAi
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting
Arl2 and Arl3 regulate different microtubule-dependent processes
ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter
Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan
Aromatase and estrogen receptor ? deficiency
Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis
Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
Aromatic-participant interactions are essential for disulfide-bond-based trimerization in human heat shock transcription factor 1
Arp2/3 ATP hydrolysis: to branch or to debranch?
Arp2/3 complex is bound and activated by two WASP proteins
Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality
Arrangement of disulfide bridges and positions of sulfhydryl groups in tetanus toxin
Articular cartilage collagen: an irreplaceable framework?
Arylamine N-acetyltransferases and drug response
Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide
AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src
ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis
Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
ASCT-1 is a neutral amino acid exchanger with chloride channel activity
AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2
Asna1/TRC40-mediated membrane insertion of tail-anchored proteins
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease
Asparaginyl endopeptidase: case history of a class II MHC compartment protease
Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
Aspects on human amyloid forms and their fibril polypeptides
Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions
Assembling a primary cilium
Assembly and budding of influenza virus
Assembly and export of MHC class I peptide ligands
Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia
Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone
Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9
Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase.
Assembly of asparagine-linked oligosaccharides
Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association
Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay
Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process
Assembly of fibronectin extracellular matrix
Assembly of heteromeric connexons in guinea-pig liver en route to the Golgi apparatus, plasma membrane and gap junctions
Assembly of high order G alpha q-effector complexes with RGS proteins
Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif
Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter
Assembly of influenza hemagglutinin trimers and its role in intracellular transport
Assembly of major histocompatibility complex class II subunits with invariant chain
Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process
Assembly of oligomeric death domain complexes during Toll receptor signaling
Assembly of simian virus 40 Okazaki pieces from DNA primers is reversibly arrested by ATP depletion.
Assembly of the human origin recognition complex
Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites
Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response
Assessment of roles of surface histidyl residues in the molecular basis of the Bohr effect and of beta 143 histidine in the binding of 2,3-bisphosphoglycerate in human normal adult hemoglobin
Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
Assignment of human beta-galactosidase-A gene to 3p21.33 by fluorescence in situ hybridization
Assignment of the gene for human arylsulfatase B, ARSB, to chromosome region 5p11----5qter
Assignment of the human and mouse prion protein genes to homologous chromosomes
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases
Association of 14-3-3gamma and phosphorylated bad attenuates injury in ischemic astrocytes
Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex
Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death
Association of alternative complement pathway components with human blood platelets: secretion and localization of factor D and beta 1H Globulin
Association of arthritis with a gene complex encoding C-type lectin-like receptors
Association of B cell antigen receptor with protein tyrosine kinase Lyn
Association of BRCA1 with Rad51 in mitotic and meiotic cells
Association of CPI-17 with protein kinase C and casein kinase I
Association of DAP12 with activating CD94/NKG2C NK cell receptors
Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling
Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity
Association of folding intermediates of glycoproteins with calnexin during protein maturation
Association of functional influenza viral proteins and RNAs with nuclear chromatin and sub-chromatin structure
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand
Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils
Association of influenza virus matrix protein with ribonucleoproteins
Association of influenza virus matrix protein with ribonucleoproteins may control viral growth and morphology
Association of influenza virus NP and M1 proteins with cellular cytoskeletal elements in influenza virus-infected cells
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection
Association of intestinal peptide transport with a protein related to the cadherin superfamily
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents
Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter
Association of RIG-I with innate immunity of ducks to influenza
Association of signal-regulatory proteins beta with KARAP/DAP-12
Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
Association of the APC gene product with beta-catenin
Association of the APC tumor suppressor protein with catenins
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells
Association of the factor VIII light chain with von Willebrand factor
Association of the hCLCA1 gene with childhood and adult asthma
Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor
Association of the human SUMO-1 protease SENP2 with the nuclear pore
Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II
Association of the p75 neurotrophin receptor with TRAF6
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo
Association of TRAF2 with the short form of cellular FLICE-like inhibitory protein prevents TNFR1-mediated apoptosis
Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
Association state of human red blood cell band 3 and its interaction with ankyrin
Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors
Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells
Asymmetric budding of viruses in epithelial monlayers: a model system for study of epithelial polarity
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals
At the right place at the right time: novel CENP-A binding proteins shed light on centromere assembly
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.
ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes
ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding
ATAC-king the complexity of SAGA during evolution
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
ATF-2 contains a phosphorylation-dependent transcriptional activation domain
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages
ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
ATM and RPA in meiotic chromosome synapsis and recombination
ATM associates with and phosphorylates p53: mapping the region of interaction.
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Atomic structure of GTP cyclohydrolase I
Atomic structures of amyloid cross-beta spines reveal varied steric zippers
ATP accelerates respiration of mitochondria from rat lung and suppresses their release of hydrogen peroxide
ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.
ATP and acetylcholine, equal brethren
ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation
ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)
ATP bound to the origin recognition complex is important for preRC formation
ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism
ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays
ATP induces nucleotide permeability in rat mast cells
ATP-binding cassette (ABC) transporters in human metabolism and diseases
ATP-Binding cassette cholesterol transporters and cardiovascular disease
ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux
ATP-dependent Ca++-extrusion from human red cells
ATP-dependent chromatin remodeling enzymes: two heads are not better, just different
ATP-dependent human RISC assembly pathways
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases
ATP-dependent positive supercoiling of DNA by 13S condensin: a biochemical implication for chromosome condensation
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
ATP-dependent transport of bile acid intermediates across rat liver peroxisomal membranes
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells
ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine
ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes
ATPase switches controlling DNA replication initiation.
ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles
ATR and ATRIP: partners in checkpoint signaling
ATR couples FANCD2 monoubiquitination to the DNA-damage response
ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes
ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
ATR-dependent phosphorylation of ATRIP in response to genotoxic stress
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
Atrial amyloid deposits in the failing human heart display both atrial and brain natriuretic peptide-like immunoreactivity
ATRIP associates with replication protein A-coated ssDNA through multiple interactions
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
ATRIP oligomerization is required for ATR-dependent checkpoint signaling
Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures
Atypical functional properties of GluK3-containing kainate receptors
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors
AU-rich elements and associated factors: are there unifying principles?
AU-rich elements and the control of gene expression through regulated mRNA stability
AUF1 Is a bcl-2 A + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis
AUF1, the regulator of tumor necrosis factor alpha messenger RNA decay, is targeted by autoantibodies of patients with systemic rheumatic diseases
Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes
Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate.
Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process
Autocatalytic activation of human legumain at aspartic acid residues
Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins
Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3)
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1
Autoinhibition of TFIIIB70 binding by the tetratricopeptide repeat-containing subunit of TFIIIC
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry
Autophagy and its role in MHC-mediated antigen presentation
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor
Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
Autoproteolysis in hedgehog protein biogenesis
Autoproteolytic activation of pro-caspases by oligomerization
Autosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANK
Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH
Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene
Averting inflammation by targeting the cytokine environment
Avian-specific TLRs and downstream effector responses to CpG-induction in chicken macrophages
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
AXIN1 mutations but not deletions in cerebellar medulloblastomas
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
Axl is essential for VEGF-A-dependent activation of PI3K/Akt
AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein
B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins
B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells
B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression.
B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands
B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex
B lymphocytes secrete antigen-presenting vesicles
B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia
B-cell receptor
B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.
B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK
Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells
Back in the water: the return of the inositol phosphates
Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase
BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
BAF is required for emerin assembly into the reforming nuclear envelope
BAG-1 modulates the chaperone activity of Hsp70/Hsc70
Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
Balancing co-stimulation and inhibition with BTLA and HVEM
Band 3 Memphis variant II. Altered stilbene disulfonate binding and the Diego (Dia) blood group antigen are associated with the human erythrocyte band 3 mutation Pro854-->Leu
Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes.
Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules
Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2
Barttin activates ClC-K channel function by modulating gating
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion
Barttin modulates trafficking and function of ClC-K channels
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
Basement membrane assembly, stability and activities observed through a developmental lens
Basement membrane complexes with biological activity
Basement membrane dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic membrane
Basement membrane structure in situ: evidence for lateral associations in the type IV collagen network
Basement membrane zone remodeling during appendageal development in human fetal skin. The absence of type VII collagen is associated with gelatinase-A (MMP2) activity
Basement-membrane heparan sulfate proteoglycan binds to laminin by its heparan sulfate chains and to nidogen by sites in the protein core
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes
Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells.
Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein
BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway
BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction
BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions
Bestrophin Cl- channels are highly permeable to HCO3-
beta 1 integrin function in vivo: adhesion, migration and more
Beta glucuronidase deficiency: report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis
Beta-2 microglobulin in ESRD: an in-depth review
Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
Beta-arrestin-mediated localization of smoothened to the primary cilium
Beta-arrestins and cell signaling
beta-catenin can be transported into the nucleus in a Ran-unassisted manner
beta-catenin destruction complex: insights and questions from a structural perspective
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
Beta-catenin hits chromatin: regulation of Wnt target gene activation
Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice
beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer
Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway
beta-Catenin shows an overlapping sequence requirement but distinct molecular interactions for its bidirectional passage through nuclear pores
Beta-cell CaV channel regulation in physiology and pathophysiology
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
Beta-enolase deficiency, a new metabolic myopathy of distal glycolysis
Beta-oxidation of long-chain fatty acids by human fibroblasts: evidence for a novel long-chain acyl-coenzyme A dehydrogenase.
Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family.
Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870
beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta
Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics
beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities
Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the laminin alpha5 chain G domain
BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells
beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development
betaIV-spectrin forms a diffusion barrier against L1CAM at the axon initial segment
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932
Better smelling through genetics: mammalian odor perception
Beyond calcium: new signaling pathways for Tec family kinases
Beyond the RING: CBL proteins as multivalent adapters
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks
Bi-modal regulation of a formin by srGAP2
BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry
Biallelic expression of nanog protein in mouse embryonic stem cells
Bicarbonate transport in cell physiology and disease
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
Bidirectional Eph-ephrin signaling during axon guidance
Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C
Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5
Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements
BIGH3 mutation spectrum in corneal dystrophies
Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix
Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures
Bile acid biosynthesis
Bile acids: natural ligands for an orphan nuclear receptor
Bile salt transporters: molecular characterization, function, and regulation
Bile salt-dependent lipase: its pathophysiological implications
Bilirubin conjugates in bile of man and rat in the normal state and in liver disease
Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins
Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1
Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation
Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6
Binding domain for laminin on type IV collagen
Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1
Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
Binding of coagulation factor XI to washed human platelets
Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site
Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
Binding of fibromodulin and decorin to separate sites on fibrillar collagens
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
Binding of hexabrachion (tenascin) to the extracellular matrix and substratum and its effect on cell adhesion
Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule
Binding of human and rat CD59 to the terminal complement complexes
Binding of human blood-coagulation Factors IXa and X to phospholipid membranes
Binding of human complement C8 to C9: role of the N-terminal modules in the C8 alpha subunit
Binding of human factor VII and VIIa to monocytes
Binding of human factor VIII to phospholipid vesicles
Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding
Binding of laminin to type IV collagen: a morphological study
Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1
Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK
Binding of MET-TRNAf and GTP to homogeneous initiation factor MP
Binding of mouse and human fibulin-2 to extracellular matrix ligands
Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens
Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6
Binding of NCK to SOS and activation of ras-dependent gene expression
Binding of netrin-4 to laminin short arms regulates basement membrane assembly
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein
Binding of nidogen and the laminin-nidogen complex to basement membrane collagen type IV
Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli
Binding of perlecan to transthyretin in vitro
Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex
Binding of serum amyloid P-component (SAP) by amyloid fibrils
Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
Binding of single-chain prourokinase to the urokinase receptor of human U937 cells
Binding of tenascin-C to soluble fibronectin and matrix fibrils
Binding of the cGMP-gated channel to the Na/Ca-K exchanger in rod photoreceptors
Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins
Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry
Binding of the proteoglycan decorin to collagen type VI
Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu
Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences
Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen
Binding studies of a triple-helical peptide model of macrophage scavenger receptor to tetraplex nucleic acids
Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution
Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3
Biochemical analysis of the human mismatch repair proteins hMutS? MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)
Biochemical analysis of the intrinsic Mcm4-Mcm6-Mcm7 DNA helicase activity
Biochemical and genetic aspects of mevalonate kinase and its deficiency
Biochemical and stability properties of recombinant human MnSOD
Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA
Biochemical and structural studies of the interaction of Cdc37 with Hsp90
Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein
Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end
Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism
Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog
Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional alpha1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis
Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA
Biochemical characterization of human collagenase-3
Biochemical characterization of human GMP synthetase
Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities
Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases
Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme
Biochemical characterization of the human copper transporter Ctr1
Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complex
Biochemical characterization of the very long-chain fatty acid elongase ELOVL7
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein
Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species
Biochemical evidence that patched is the Hedgehog receptor
Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE)
Biochemical Pathways - An Atlas of Biochemistry and Molecular Biology
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching
Biochemical signals and biological responses elicited by the focal adhesion kinase
Biochemistry - The Chemical Reactions of Living Cells 2nd Edn.
Biochemistry and cell biology of mammalian scavenger receptors
Biochemistry of hyaluronan
Biochemistry of mammalian peroxisomes revisited
Biochemistry of signal transduction and regulation
Biochemistry of soluble guanylate cyclase
Biochemistry of the initial steps of mycothiol biosynthesis
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
Bioenergetics 3
Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core
Biogenesis and function of fibrillin assemblies
Biogenesis and regulation of insulin-responsive vesicles containing GLUT4
Biogenesis of eukaryotic cytochrome c oxidase
Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly
Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease
Biogenesis of mitochondrial proteins
Biogenesis of small RNAs in animals
Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40
Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway
Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway
Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins
Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria
Bioinformatics and type II G-protein-coupled receptors
Biological & physiological aspects of action of insulin-like growth factor peptide family
Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor
Biological characterization of angiopoietin-3 and angiopoietin-4
Biological characterization of various forms of elongation factor 1 from rabbit reticulocytes
Biological consequences of overexpressing or eliminating N-acetylglucosaminyltransferase-TIII in the mouse
Biological degradation of aflatoxins
Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease
Biological Function of the Cellular Lipid BMP-BMP as a Key Activator for Cholesterol Sorting and Membrane Digestion
Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D
Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1
Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction
Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization
Biological roles and mechanistic actions of co-repressor complexes
Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
Biology and pathology of nectins and nectin-like molecules
Biology of endocannabinoid synthesis system
Biology of incretins: GLP-1 and GIP
Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines
Biology of the p21-activated kinases
Biology, structure and mechanism of P-type ATPases
Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment
Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria
Biosynthesis and metabolism of leukotrienes
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration
Biosynthesis of chick type VI collagen. I. Intracellular assembly and molecular structure
Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches
Biosynthesis of chondroitin/dermatan sulfate
Biosynthesis of collagen crosslinks: increased activity of purified lysyl oxidase with reconstituted collagen fibrils
Biosynthesis of decorin and glypican
Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man
Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2
Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects.
Biosynthesis of heme in mammals
Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties
Biosynthesis of prothrombin: intracellular localization of the vitamin K-dependent carboxylase and the sites of gamma-carboxylation
Biosynthesis of tetrahydrobiopterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)
Biosynthesis of the purines. XXIX. Purification and properties of formylglycinamide ribonucleotide amidotransferase from chicken liver
Biosynthesis of the purines. XXXV. Reversible polymerization of formylglycinamide ribonucleotide amidotransferase
Biosynthesis of thyroid hormone: basic and clinical aspects
Biosynthesis of triacylglycerols
Biosynthesis of tricarboxylic acids by carbon dioxide fixation; enzymatic mechanisms
Biosynthesis, intracellular transport and enzymatic activity of an avian influenza A virus neuraminidase: role of unpaired cysteines and individual oligosaccharides
Biosynthetic and structural properties of endothelial cell type VIII collagen
Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin
Biotechnology and the chicken B cell line DT40
Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system
Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2
Biotinidase and its roles in biotin metabolism
Biotinidase deficiency: "if you have to have an inherited metabolic disease, this is the one to have"
Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase deficiency
Biotinylation of biotinidase following incubation with biocytin
Biotransformation of xenobiotics by amine oxidases
Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex
Blinded by the Light: The Growing Complexity of p53
BLM SUMOylation regulates ssDNA accumulation at stalled replication forks
BLNK mediates Syk-dependent Btk activation
BLNK: a central linker protein in B cell activation
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins
Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes
BLT1 and BLT2: the leukotriene B(4) receptors
BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer
BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
Boc is a receptor for sonic hedgehog in the guidance of commissural axons
BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation
Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain
Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors
Bone morphogenetic protein receptors and signal transduction
Bone morphogenetic protein-1 (BMP-1) cleaves human proapolipoprotein A1 and regulates its activation for lipid binding
Bone morphogenetic protein-1 (BMP-1) mediates C-terminal processing of procollagen V homotrimer
Bone morphogenetic proteins
Bone morphogenetic proteins and their antagonists
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel
Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis
Both isoforms of ketohexokinase are dispensable for normal growth and development
Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase
Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells
Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells
Both substrate and target oligonucleotide sequences affect in vitro integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.
Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W
Botulinum and tetanus neurotoxins: structure, function and therapeutic utility
Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin
Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: correlation with its blockade of catecholamine release
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins
Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity
Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry
Botulinum neurotoxin type A: cleavage of the heavy chain into two halves and their partial sequences
Botulinum neurotoxin type B (strain 657): partial sequence and similarity with tetanus toxin
Botulinum neurotoxin type E fragmented with endoproteinase Lys-C reveals the site trypsin nicks and homology with tetanus neurotoxin
Botulinum neurotoxin type G proteolyses the Ala81-Ala82 bond of rat synaptobrevin 2
Botulinum neurotoxin: a marvel of protein design
Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
Botulism: the present status of the disease
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages
Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member
Brca1 in immunoglobulin gene conversion and somatic hypermutation
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation
BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes
BRCA2-dependent and independent formation of RAD51 nuclear foci.
Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription
Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites
BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein
Bridging structure with function: structural, regulatory, and developmental role of laminins
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
Broad expression of Toll-like receptors in the human central nervous system
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain
Brown adipose tissue: function and physiological significance
Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment
Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54
BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
Bruton's Tyrosine Kinase is involved in innate and adaptive immunity
Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production
Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response
Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit
BTKbase: the mutation database for X-linked agammaglobulinemia
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
Buffer dependence of CO2 hydration catalyzed by human carbonic anhydrase I
Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III
Building collagen molecules, fibrils, and suprafibrillar structures
Building ubiquitin chains: E2 enzymes at work
Burkholderia is highly resistant to human Beta-defensin 3
By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
Bypass of N²-ethylguanine by human DNA polymerase ?
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
Bypass specialists operate together
C'1 esterase effect on activity and physicochemical properties of the fourth component of complement
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance
C-cadherin ectodomain structure and implications for cell adhesion mechanisms
c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway
c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-? type II receptor
c-FLIP is involved in erythropoietin-mediated protection of erythroid-differentiated cells from TNF-alpha-induced apoptosis
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
c-FLIPR, a new regulator of death receptor-induced apoptosis
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
c-Jun expression, activation and function in neural cell death, inflammation and repair
c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity
c-Kit--a hematopoietic cell essential receptor tyrosine kinase
C-mannosylation and O-fucosylation of the thrombospondin type 1 module
C-mannosylation and o-fucosylation of thrombospondin type 1 repeats
C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity
c-Src: bridging the gap between phosphorylation- and acidification-induced gap junction channel closure
C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases
C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II
C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?
C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
C-to-U RNA editing: mechanisms leading to genetic diversity.
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity
C-type lectin MCL is an FcR?-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways
C/EBP?'s role in determining Ras-induced senescence or transformation
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway
C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer
C1 domains exposed: from diacylglycerol binding to protein-protein interactions
C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains.
C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited
C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells
C1q: structure, function, and receptors
C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane
C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals
C2cd3 is required for cilia formation and Hedgehog signaling in mouse
C3 nephritic factor protects bound C3bBb from cleavage by factor I and human erythrocytes
C3 requirements for formation of alternative pathway C5 convertase
C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
C4b-binding protein inhibits the factor V-dependent but not the factor V-independent cofactor activity of protein S in the activated protein C-mediated inactivation of factor VIIIa
C5 convertase of the alternative complement pathway: covalent linkage between two C3b molecules within the trimolecular complex enzyme
C5 convertase of the alternative pathway of complement. Kinetic analysis of the free and surface-bound forms of the enzyme
C5a-stimulated recruitment of beta-arrestin2 to the nonsignaling 7-transmembrane decoy receptor C5L2
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin
Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.
Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus
Ca2+ entry, efflux and release in smooth muscle
Ca2+ permeability of nicotinic acetylcholine receptors
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages
Ca2+-activated ATPase in microsomes from human liver
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
Ca2+-induced Ca2+ release by activation of inositol 1,4,5-trisphosphate receptors in primary pancreatic beta-cells
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure
Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly
Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol
Cajal bodies: the first 100 years.
Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein
Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity
Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers
Calcineurin: form and function
Calcitonin gene-related peptide (CGRP) receptors are linked to cyclic adenosine monophosphate production in SK-N-MC human neuroblastoma cells
Calcium and magnesium fluxes across the plasma membrane of the toad rod outer segment
Calcium channels in thrombin-activated human platelet membrane
Calcium depletion dissociates and activates heterodimeric notch receptors
Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation
Calcium signaling
Calcium signaling in platelets
Calcium signalling in lymphocyte activation and disease
Calcium signalling--an overview
Calcium signalling: past, present and future
Calcium-activated opsin phosphatase activity in retinal rod outer segments
Calcium-containing platelet granules
Calcium-sensitive control of rhodopsin phosphorylation in the reconstituted system consisting of photoreceptor membranes, rhodopsin kinase and recoverin
Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
CalDAG-GEFIII activation of Ras, R-ras, and Rap1
CalfRTH-1 nuclease can remove the initiator RNAs of Okazaki fragments by endonuclease activity.
Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS
Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein
Calmodulin-binding sites on adenylyl cyclase type VIII
Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1)
Calmodulin-kinases: modulators of neuronal development and plasticity
Calmodulin-regulated adenylyl cyclases and neuromodulation.
Calmodulin: a prototypical calcium sensor
Calnexin influences folding of human class I histocompatibility proteins but not their assembly with beta 2-microglobulin
Calprotectin inhibits matrix metalloproteinases by sequestration of zinc
Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I
Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase
Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules
Calsequestrin and the calcium release channel of skeletal and cardiac muscle
CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells
cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes
Can a GDP-liganded G-protein be active?
Can type VII collagen injections cure dystrophic epidermolysis bullosa?
Cancer biology: a new RING to Wnt signaling
Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
Candidate cell and matrix interaction domains on the collagen fibril, the predominant protein of vertebrates
Canonical and non-canonical Notch ligands
Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins
Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding
Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo
Capsid is a dominant determinant of retrovirus infectivity in nondividing cells
Capture of an early fusion-active conformation of HIV-1 gp41
Carbamino compounds of haemoglobin in human adult and foetal blood
Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
Carbohydrate deficient serum transferrin in a new systemic hereditary syndrome
Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin
Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage
Carbohydrate signaling by C-type lectin DC-SIGN affects NF-kappaB activity
Carbon 13 resonances of 13CO2 carbamino adducts of alpha and beta chains in human adult hemoglobin
Carbon dioxide and oxygen linkage in human hemoglobin tetramers
Carbon dioxide transport and carbonic anhydrase in blood and muscle
Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors
Carbonic anhydrase inhibitors: inhibition of human and murine mitochondrial isozymes V with anions
Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different
Carbonic anhydrase IV activity is localized on the exterior surface of human erythrocytes
Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney
Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity
Carboxy-terminal conversion of profibrillin to fibrillin at a basic site by PACE/furin-like activity required for incorporation in the matrix
Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
Carboxylases in de novo purine biosynthesis. Characterization of the Gallus gallus bifunctional enzyme
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B
CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans
CARD9 versus CARMA1 in innate and adaptive immunity
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2
Cardiolipin is synthesized on the matrix side of the inner membrane in rat liver mitochondria
CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase
Carnitine biosynthesis: identification of the cDNA encoding human gamma-butyrobetaine hydroxylase
Carnitine palmitoyltransferase II deficiency: structure of the gene and characterization of two novel disease-causing mutations
Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5
Cartilage contains mixed fibrils of collagen types II, IX, and XI
Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage
Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes
Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin
Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen
Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins
Cartilage proteoglycan binding region and link protein. Radioimmunoassays and the detection of masked determinants in aggregates
CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
Casarett and Doull's Toxicology 5th Edn
Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
Casein kinase 2 associates with and phosphorylates dishevelled
Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin
Casein kinase I in the mammalian circadian clock
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex
Casein kinase I transduces Wnt signals
Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function
Casein kinase II phosphorylates the neural cell adhesion molecule L1
Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin
Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis
Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site
Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
Caspase-10 is an initiator caspase in death receptor signaling
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis
Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis
Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines
Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases
Caspase-8-mediated apoptosis in human RPE cells
Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
Caspase-activation pathways in apoptosis and immunity
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis
Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain
Caspases leave the beaten track: caspase-mediated activation of NF-kappaB
Casper is a FADD- and caspase-related inducer of apoptosis
CASVM: web server for SVM-based prediction of caspase substrates cleavage sites
Catabolism of intact fibrillin microfibrils by neutrophil elastase, chymotrypsin and trypsin
Catabolism of polyamines
Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase
Catalase, a target of glycation damage in rat liver mitochondria with aging
Catalysis and function of the p38 alpha.MK2a signaling complex
Catalysis and inhibition of human carbonic anhydrase IV
Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH
Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain
Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion
Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
Catalytic cycle of human glutathione reductase near 1 A resolution
Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator
Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures
Catalytic mechanism of a MYST family histone acetyltransferase
Catalytic pathway of manganese superoxide dismutase by direct observation of superoxide
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis
Catalytic properties of human manganese superoxide dismutase
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase
Catecholamine biosynthesis and physiological regulation in neuroendocrine cells
Catecholamines: role in health and disease
CATERPILLERs, pyrin and hereditary immunological disorders
Cathelicidins: a family of endogenous antimicrobial peptides
Cathepsin B, Cathepsin H, and cathepsin L
Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus
Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation
Cathepsin S required for normal MHC class II peptide loading and germinal center development
Cathepsins are required for Toll-like receptor 9 responses
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
Cationic lipids activate cellular cascades. Which receptors are involved?
CATs and HATs: the SLC7 family of amino acid transporters
Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix
Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors
CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling
Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
Cbl-mediated ubiquitinylation and negative regulation of Vav
Cbl: many adaptations to regulate protein tyrosine kinases
CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families
cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression
CBP and p300: HATs for different occasions
CBP/p300 in cell growth, transformation, and development
CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP)
CCDC41 is required for ciliary vesicle docking to the mother centriole
CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B
CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11
CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase
CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains.
CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand
CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
CD147 and its interacting proteins in cellular functions
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin
CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin
CD19 function in central and peripheral B-cell development
CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses
Cd19-dependent activation of Akt kinase in B-lymphocytes
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2
CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription
CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?
CD28-mediated co-stimulation: a quantitative support for TCR signalling
CD28/CTLA-4 and CD80/CD86 families: signaling and function
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere
CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain
CD303 (BDCA-2) signals in plasmacytoid dendritic cells via a BCR-like signalosome involving Syk, Slp65 and PLCgamma2
CD31 (PECAM-1) exists as a dimer and is heavily N-glycosylated
CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium
CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis
CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
CD36 is a receptor for oxidized low density lipoprotein
CD36 is a sensor of diacylglycerides
CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails
CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart
CD36 N-terminal cytoplasmic domain is not required for the internalization of oxidized low-density lipoprotein
CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization
CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system
CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
CD44 is a major E-selectin ligand on human hematopoietic progenitor cells
CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
CD44-mediated uptake and degradation of hyaluronan
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells
CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells
CD59 efficiently protects human NT2-N neurons against complement-mediated damage
CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1
Cdc13 delivers separate complexes to the telomere for end protection and replication
Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis
Cdc25 cell-cycle phosphatase as a target of c-myc
Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import
Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation
Cdc42 and mDia3 regulate microtubule attachment to kinetochores
Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin
Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin
Cdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation
Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast
Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
CDG nomenclature: time for a change!
CDG-Id in two siblings with partially different phenotypes
CDG-IL: an infant with a novel mutation in the ALG9 gene and additional phenotypic features
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
CDK2 is required for proper homologous pairing, recombination and sex-body formation during male mouse meiosis
Cdk2-dependent and -independent pathways in E2F-mediated S phase induction
Cdk4 promotes adipogenesis through PPARgamma activation
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids
cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid
cDNA cloning and characterization of neuron-specific enolase from chicken
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria
cDNA cloning and expression of a new form of human aryl sulfotransferase
cDna cloning and expression of CYP4F12, a novel human cytochrome P450
cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster
cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13
cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450
cDNA cloning and mapping of a novel subtype of glutamine:fructose-6-phosphate amidotransferase (GFAT2) in human and mouse
cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12
cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme
cDNA cloning of human R-type pyruvate kinase and identification of a single amino acid substitution (Thr384----Met) affecting enzymatic stability in a pyruvate kinase variant (PK Tokyo) associated with hereditary hemolytic anemia
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
cDNA cloning of the beta-subunit of the human gastric H,K-ATPase
cDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein
cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence
cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase
cDNA cloning, expression and characterization of human prostaglandin F synthase
cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)
cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase
cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor
cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase:
cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)
cDNA sequence and heterologous expression of the human neurokinin-3 receptor
cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A
cDNA-derived primary structure of the 25-kDa subunit of canine microsomal signal peptidase complex
cDNA-derived primary structure of the glycoprotein component of canine microsomal signal peptidase complex
Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway
CDO, a robo-related cell surface protein that mediates myogenic differentiation
Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
Cell adhesion and integrin binding to recombinant human fibrillin-1
Cell adhesion and integrin binding to recombinant human fibrillin-1
Cell adhesion mechanisms in platelets
Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion
Cell adhesion molecules: signalling functions at the synapse
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins
Cell adhesion: the molecular basis of tissue architecture and morphogenesis
Cell biology of heme
Cell biology of IL-7, a key lymphotrophin
Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1
Cell cycle and death control: long live Forkheads
Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint
Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
Cell cycle regulation of PML modification and ND10 composition
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.
Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3
Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin
Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres
Cell cycle-dependent regulation of yeast telomerase by Ku
Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton
Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast
Cell cycle-regulated trafficking of human telomerase to telomeres
Cell cycling through Cdc25A: transducer of cytokine proliferative signals
Cell death modalities: classification and pathophysiological implications
Cell division: the heart of the cycle
Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex
Cell lines derived from avian lymphomas exhibit two distinct phenotypes
Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate
Cell physiology of cAMP sensor Epac
Cell responses to FGFR3 signalling: growth, differentiation and apoptosis
Cell signaling by receptor tyrosine kinases
Cell signaling by receptor tyrosine kinases
Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins
Cell signalling through thromboxane A2 receptors
Cell surface expression and metabolism of major histocompatibility complex class II invariant chain (CD74) by diverse cell lines
Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60
Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences
Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
Cell surface proteoglycan binds mouse mammary epithelial cells to fibronectin and behaves as a receptor for interstitial matrix
Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
Cell- and receptor isotype-specific phosphorylation of SNT1 by fibroblast growth factor receptor tyrosine kinases
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
Cell-cell signaling via Eph receptors and ephrins
Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells
Cell-free synthesis and assembly of connexins into functional gap junction membrane channels
Cell-free synthesis of procollagen: L-929 fibroblasts as a cellular model for dermatosparaxis
Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring
Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1
Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin
Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS
Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress
Cellular actions of the insulin-like growth factor binding proteins
Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway
Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS
Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)
Cellular circadian pacemaking and the role of cytosolic rhythms
Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2)
Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma
Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8
Cellular FLIP(L) plays a survival role and regulates morphogenesis in breast epithelial cells
Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth
Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina
Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme
Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
Cellular reactive oxygen species inhibit MPYS induction of IFN?
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.
Cellular recognition and trafficking of amorphous silica nanoparticles by macrophage scavenger receptor A
Cellular regulation of endothelial nitric oxide synthase
Cellular regulation of RGS proteins: modulators and integrators of G protein signaling
Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)
Cellular responses to interferon-gamma
Cellular senescence in cancer and aging
Cellular senescence: when bad things happen to good cells
Cellular signaling by fibroblast growth factor receptors
Cellular signalling mechanisms of neural cell adhesion molecules
Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin
CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells
CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase
Central insulin and leptin-mediated autonomic control of glucose homeostasis
Central leptin and ghrelin signalling: comparing and contrasting their mechanisms of action in the brain
Central leptin receptor action and resistance in obesity
Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity
Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis
Centriole distal appendages promote membrane docking, leading to cilia initiation
Centriole structure
Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells
Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP
Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis
Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex
Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Centrosomes and cilia in human disease
Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole
CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
Cep97 and CP110 suppress a cilia assembly program
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization
Cerebrotendinous xanthomatosis caused by two new mutations of the sterol-27-hydroxylase gene that disrupt mRNA splicing
Ceruloplasmin in neurodegenerative diseases
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
cGMP phosphodiesterase of retinal rods is regulated by two inhibitory subunits
cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells
Chain gangs: new aspects of hyaluronan metabolism
Changes in glycosylation of vitronectin modulate multimerization and collagen binding during liver regeneration
Changes in histones H2A and H3 variant composition in differentiating and mature rat brain cortical neurons
Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver
Changes in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action
Changes in protein composition of meiotic nodules during mammalian meiosis
Changes in serotonin metabolism during treatment with the aldehyde dehydrogenase inhibitors disulfiram and cyanamide
Changing genes; losing lactase
Channel-opening kinetics of GluR2Q(flip) AMPA receptor: a laser-pulse photolysis study
Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay
Chaperone selection during glycoprotein translocation into the endoplasmic reticulum
Chaperone-assisted production of active human Rab8A GTPase in Escherichia coli
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin
Chaperonins: The hunt for the Group II mechanism
Chapter 3 Regulators of G Protein Signaling Proteins as Central Components of G Protein-Coupled Receptor Signaling Complexes
Characterisation of 1,4-benzothiazine intermediates in the oxidative conversion of 5-S-cysteinyldopa to pheomelanins
Characterisation of a type-I collagen trimeric cross-linked peptide from calf aorta and its cross-linked structure. Detection of pyridinoline by time-of-flight secondary ion-mass spectroscopy and evidence for a new cross-link
Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion
Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress
Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies
Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma
Characteristics of 92 kDa type IV collagenase/gelatinase produced by granulocytic leukemia cells: structure, expression of cDNA in E. coli and enzymic properties
Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95
Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition
Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms
Characterization and chromosomal localization of the gene for human rhodopsin kinase
Characterization and comparative structural features of the gene for human interstitial retinol-binding protein
Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells
Characterization and expression of the human A2a adenosine receptor gene
Characterization and functional analysis of the murine Frat2 gene
Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters
Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase
Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan
Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas
Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene
Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family
Characterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen
Characterization and regulation of the rat and human ghrelin promoters
Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2
Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase
Characterization of 16 novel human genes showing high similarity to yeast sequences
Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain
Characterization of a C3a receptor in rainbow trout and Xenopus: the first identification of C3a receptors in nonmammalian species
Characterization of a cDNA coding for human factor VII
Characterization of a cDNA coding for human factor X
Characterization of a cDNA coding for human protein C
Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis
Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase
Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3
Characterization of a fourth adaptor-related protein complex
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop
Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione
Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase
Characterization of a heart-specific fatty acid transport protein
Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein
Characterization of a human cDNA that encodes a functional receptor for platelet activating factor
Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus
Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia
Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1
Characterization of a microsomal subfraction associated with mitochondria of the yeast, Saccharomyces cerevisiae. Involvement in synthesis and import of phospholipids into mitochondria
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay
Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex
Characterization of a novel sphingosine 1-phosphate receptor, Edg-8
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity
Characterization of a second member of the sentrin family of ubiquitin-like proteins
Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1
Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes
Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1
Characterization of affinity-purified type I insulin-like growth factor receptor from human placenta
Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism
Characterization of an associated microfibril protein through recombinant DNA techniques
Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63
Characterization of arachidonic acid metabolites through the 12-lipoxygenase pathway in human epidermis by high-performance liquid chromatography and gas chromatography/mass spectrometry
Characterization of ATP and calmodulin-binding properties of a truncated form of Bacillus anthracis adenylate cyclase
Characterization of beta-glucan recognition site on C-type lectin, dectin 1
Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization
Characterization of cDNA for precursor of human luteinizing hormone releasing hormone
Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover
Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes
Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells
Characterization of collagen types XII and XIV from fetal bovine cartilage
Characterization of complement activity in turkeys: evidence for classical and alternative complement pathways
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction
Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells
Characterization of defensin precursors in mature human neutrophils
Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase
Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp
Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE
Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation
Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis
Characterization of GPRA, a novel G protein-coupled receptor related to asthma
Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells
Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro
Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas
Characterization of human carbonic anhydrase III from skeletal muscle
Characterization of human cardiac calsequestrin and its deleterious mutants
Characterization of human D-amino acid oxidase
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
Characterization of human FAST-1, a TGF beta and activin signal transducer
Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle
Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.
Characterization of human iodothyronine sulfotransferases
Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate
Characterization of human lysophospholipid acyltransferase 3
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis
Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis
Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin
Characterization of human platelet GTPase activating protein for the Ral GTP-binding protein
Characterization of human PLD2 and the analysis of PLD isoform splice variants
Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis
Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits
Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity
Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
Characterization of human type I and type II IMP dehydrogenases
Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations
Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.
Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells
Characterization of insulin-like growth factor-free interaction between insulin-like growth factor binding protein 3 and acid labile subunit expressed from Xenopus oocytes
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1
Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis
Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family
Characterization of mammalian eIF4E-family members
Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import
Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis
Characterization of mouse IFT complex B
Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity
Characterization of multiple adhesive and counteradhesive domains in the extracellular matrix protein cytotactin
Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9
Characterization of Na+/HCO-3 cotransporter isoform NBC-3
Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120
Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes
Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles
Characterization of orphan human cytochromes P450
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex
Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B
Characterization of Pellino2, a substrate of IRAK1 and IRAK4
Characterization of phospholipase D activity in bovine photoreceptor membranes
Characterization of photolyase/blue-light receptor homologs in mouse and human cells
Characterization of pluripotent stem cells
Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein
Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma
Characterization of protein synthesis factors from rabbit reticulocytes
Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
Characterization of rabbit skeletal muscle glycogenin. Tyrosine 194 is essential for function.
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor
Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases
Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis
Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV
Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2
Characterization of recombinant soluble macrophage scavenger receptor MARCO
Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor
Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.
Characterization of S-100b binding epitopes. Identification of a novel target, the actin capping protein, CapZ
Characterization of Slit protein interactions with glypican-1
Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex
Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans
Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases
Characterization of temperature sensitive influenza virus mutants defective in neuraminidase
Characterization of the 5'-flanking region of the rat gene for mitochondrial transcription factor A (Tfam)
Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein
Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells
Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit.
Characterization of the avian GLUT1 glucose transporter: differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts
Characterization of the binding domains in the fragments cleaved by cathepsin G from human plasma fibronectin
Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis
Characterization of the chicken aldolase B gene
Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes
Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids
Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin
Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene
Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate
Characterization of the denaturation and renaturation of human plasma vitronectin. I. Biophysical characterization of protein unfolding and multimerization
Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII
Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells
Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase
Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41
Characterization of the gene encoding human cone transducin alpha-subunit (GNAT2)
Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase (ACAA). No large DNA rearrangement in a thiolase-deficient patient
Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system
Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques
Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family
Characterization of the human antizyme gene
Characterization of the human beta -glucan receptor and its alternatively spliced isoforms
Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins
Characterization of the human cysteinyl leukotriene 2 receptor
Characterization of the human cysteinyl leukotriene CysLT1 receptor
Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity
Characterization of the human gene (TBXAS1) encoding thromboxane synthase
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)
Characterization of the human mitochondrial methionyl-tRNA synthetase
Characterization of the human Na,K-ATPase alpha 2 gene and identification of intragenic restriction fragment length polymorphisms
Characterization of the human prolyl 4-hydroxylase tetramer and its multifunctional protein disulfide-isomerase subunit synthesized in a baculovirus expression system
Characterization of the human prolyl 4-hydroxylase tetramer and its multifunctional protein disulfide-isomerase subunit synthesized in a baculovirus expression system
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
Characterization of the human rod transducin alpha-subunit gene
Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue
Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein
Characterization of the interaction of human C4b-binding protein with physiological ligands
Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors
Characterization of the interactions of the nephrin intracellular domain
Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism
Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1
Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase
Characterization of the mechanisms controlling Greatwall activity
Characterization of the membrane association of the influenza virus matrix protein in living cells
Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo.
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases
Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity
Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2
Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E
Characterization of the oligomer structure of recombinant human mannan-binding lectin
Characterization of the omega class of glutathione transferases
Characterization of the physical interaction of Gli proteins with SUFU proteins
Characterization of the polyadenylation signal of influenza virus RNA
Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions
Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains
Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer
Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes
Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis
Characterization of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
Characterization of the XRN1 gene encoding a 5'-->3' exoribonuclease: sequence data and analysis of disparate protein and mRNA levels of gene-disrupted yeast cells
Characterization of three types of human alpha s1-casein mRNA transcripts
Characterization of TNF-induced caspase-independent necroptosis
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)
Characterization of two genes for the human Na,K-ATPase beta subunit
Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line
Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes
Characterization of two isoforms of a human DnaJ homologue, HSJ2
Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver
Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments
Characterization of type V collagenase (gelatinase) in synovial fluid of patients with inflammatory arthritis
Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase
Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B
Characterization of unique binding kinetics of follistatin and activin or inhibin in serum
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells
Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue
Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray
Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentation
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
Chemical analysis of late stages of pheomelanogenesis: conversion of dihydrobenzothiazine to a benzothiazole structure
Chemical analysis of melanins and its application to the study of the regulation of melanogenesis
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Chemical mechanisms of histone lysine and arginine modifications
Chemistry and functional distribution of sulfoglycolipids
Chemistry of collagen cross-linking: biochemical changes in collagen during the partial mineralization of turkey leg tendon
Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
Chemokine receptors
Chemokine receptors and their role in inflammation and infectious diseases
Chemokine signaling via the CXCR2 receptor reinforces senescence
Chemokine-chemokine receptor network in immune cell trafficking
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity
Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation
Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway
Chicken alpha-enolase but not beta-enolase has a Src-dependent tyrosine-phosphorylation site: cDNA cloning and nucleotide sequence analysis
Chicken CD14, unlike mammalian CD14, is trans-membrane rather than GPI-anchored
Chicken FK506-binding protein, FKBP65, a member of the FKBP family of peptidylprolyl cis-trans isomerases, is only partially inhibited by FK506
Chicken ornithine transcarbamylase gene, structure, regulation, and chromosomal assignment: repetitive sequence motif in intron 3 regulates this enzyme activity
Chicken ornithine transcarbamylase: purification and some properties
Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol
Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides
Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9
Chicken toll-like receptor 3 recognizes its cognate ligand when ectopically expressed in human cells
Chicken triosephosphate isomerase complements an Escherichia coli deficiency
Chimeric mutagenesis of putative G-protein coupling domains of the alpha2A-adrenergic receptor. Localization of two redundant and fully competent gi coupling domains
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription
CHIP28 water channels are localized in constitutively water-permeable segments of the nephron
CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
Chk1 and Chk2 kinases in checkpoint control and cancer
Chk1 in the DNA damage response: conserved roles from yeasts to mammals
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.
Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons
Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
Cholecystokinin and gastrin receptors
Cholecystokinin receptors
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression
Cholesterol biosynthesis and metabolism
Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein.
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
Cholesterol modification of hedgehog signaling proteins in animal development
Cholesterol modification restricts the spread of Shh gradient in the limb bud
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning
Cholesterol sulfate in human physiology: what's it all about?
Cholesterol, hydroxycholesterols, and bile acids
Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles
Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARalpha
Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities
Chondroitin sulfate synthase-3. Molecular cloning and characterization
Chondrosarcoma in three brothers. A pathological and genetic study
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis
Chromatin higher-order structures and gene regulation
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail
Chromatin modifications and their function
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
Chromatin organization in the mammalian nucleus
Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways
Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites
Chromokinesins: multitalented players in mitosis
Chromosomal localization and cDNA cloning of the human DBP and TEF genes
Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger
Chromosomal localization of the gene for human glucosamine-6-sulphatase to 12q14
Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7
Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos
Chromosome condensation by a human condensin complex in Xenopus egg extracts
Chromosome structure and human immunodeficiency virus type 1 cDNA integration: centromeric alphoid repeats are a disfavored target
Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
Chymase cleavage of stem cell factor yields a bioactive, soluble product
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
Cilia and Hedgehog responsiveness in the mouse
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP
Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4
Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling
Ciliogenesis: building the cell's antenna
Ciliopathies: the trafficking connection
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells
CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10
Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation
Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
Circadian oscillation of a mammalian homologue of the Drosophila period gene
Circadian regulation of cryptochrome genes in the mouse
Circadian regulator CLOCK is a histone acetyltransferase
Circadian Transcription. Thinking outside the E-Box
Circularization of human immunodeficiency virus type 1 DNA in vitro
Circulating angiogenic factors and the risk of preeclampsia
Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha
Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A
cis-Acting packaging signals in the influenza virus PB1, PB2, and PA genomic RNA segments
Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria
Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
Citron kinase controls a molecular network required for midbody formation in cytokinesis
Citron kinase mediates transition from constriction to abscission through its coiled-coil domain
Citron kinase, a Rho-dependent kinase, induces di-phosphorylation of regulatory light chain of myosin II
Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron
Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus
Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation
CK2alpha phosphorylates BMAL1 to regulate the mammalian clock
CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock
CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins
CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV
Clamping down on clamps and clamp loaders--the eucaryotic replication factor C.
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
Claspin, a regulator of Chk1 in DNA replication stress pathway
Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages
Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum
Class II histone deacetylases: from sequence to function, regulation, and clinical implication
Class II histone deacetylases: versatile regulators
Class II MHC peptide loading by the professionals
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function
Classification and nomenclature of somatostatin receptors
Clathrin-independent endocytosis of ubiquitinated cargos
Claudins and epithelial paracellular transport
Claudins in occluding junctions of humans and flies
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation
ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Cleavage and activation of a Toll-like receptor by microbial proteases
Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
Cleavage and shedding of E-cadherin after induction of apoptosis
Cleavage of 14-3-3 protein by caspase-3 facilitates bad interaction with Bcl-x(L) during apoptosis
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide
Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator
Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway
Cleavage of focal adhesion kinase by caspases during apoptosis
Cleavage of human corneal type VI collagen alpha 3 chain by matrix metalloproteinase-2
Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein
Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies
Cleavage of structural components of mammalian vitreous by endogenous matrix metalloproteinase-2
Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
Cleavage of the star strand facilitates assembly of some microRNAs into Ago2-containing silencing complexes in mammals
Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis
Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin
Cleavage of type VIII collagen by human neutrophil elastase
Cleavage of type XI collagen fibers by gelatinase and by extracts of osteoarthritic canine cartilage
Cleavage preferences of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease) on naked DNA and chromatin substrates
Cleavage site specificity and conformational selection in type I collagen degradation
Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.
CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses
CLEC5A is critical for dengue-virus-induced lethal disease
CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels
CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression
Clinical and biochemical manifestations of hyaluronidase deficiency
Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency
Clinical and genetic spectrum of Sanfilippo type C (MPS IIIC) disease in The Netherlands
Clinical and molecular analysis of a Japanese boy with Morquio B disease
Clinical and molecular characterization of the first adult congenital disorder of glycosylation (CDG) type Ic patient
Clinical and molecular characterization of the first adult congenital disorder of glycosylation (CDG) type Ic patient
Clinical and molecular diagnosis of cerebrotendinous xanthomatosis with a review of the mutations in the CYP27A1 gene
Clinical and molecular features of Joubert syndrome and related disorders
Clinical and molecular features of three patients with congenital disorders of glycosylation type Ih (CDG-Ih) (ALG8 deficiency)
Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency
Clinical features of congenital myasthenic syndrome due to mutations in DPAGT1
Clinical findings and biochemical and molecular analysis of four patients with holocarboxylase synthetase deficiency
Clinical issues and frequent questions about biotinidase deficiency
Clinical Overview of HIV Disease
Clinical pharmacokinetics and pharmacodynamics of insulin glulisine
Clinical phenotype variability in patients with hereditary spastic paraplegia type 5 associated with CYP7B1 mutations
Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: neural and immune inputs
Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency
CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock
CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP
CLOCK-mediated acetylation of BMAL1 controls circadian function
CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter
Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases
Cloning and characterisation of the chicken gene encoding the telomeric protein TRF2
Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7
Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16
Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network
Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
Cloning and characterization of a histone deacetylase, HDAC9
Cloning and characterization of a histone deacetylase, HDAC9
Cloning and characterization of a human angiotensin II type 1 receptor
Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity
Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin
Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure
Cloning and characterization of a human type II receptor for bone morphogenetic proteins
Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue
Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide
Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor
Cloning and characterization of a novel human histone deacetylase, HDAC8
Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle
Cloning and Characterization of a Novel Isoform of Iodotyrosine Dehalogenase 1 (DEHAL1) DEHAL1C from Human Thyroid: Comparisons with DEHAL1 and DEHAL1B
Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells
Cloning and characterization of a novel matrix metalloproteinase (MMP), CMMP, from chicken embryo fibroblasts. CMMP, Xenopus XMMP, and human MMP19 have a conserved unique cysteine in the catalytic domain
Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney
Cloning and characterization of a novel regulator of G protein signalling in human platelets
Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt
Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1
Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family
Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1)
Cloning and characterization of cDNA encoding human A-type endothelin receptor
Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase
Cloning and characterization of Gallus and Xenopus ferrochelatases: presence of the [2Fe-2S] cluster in nonmammalian ferrochelatase
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae
Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2)
Cloning and characterization of human agmatinase
Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency
Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.
Cloning and characterization of human histone deacetylase 8
Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder
Cloning and characterization of human protease-activated receptor 4
Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B
Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue
Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production
Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart
Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases
Cloning and characterization of novel mouse and human secretory phospholipase A(2)s
Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human
Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line
Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes
Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family
Cloning and characterization of the aroA gene from Mycobacterium tuberculosis
Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor
Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase
Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family
Cloning and characterization of the human ADH4 gene
Cloning and characterization of the human beta-glucuronidase gene
Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid
Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site
Cloning and characterization of the human granulocyte chemotactic protein-2 gene
Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)
Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene
Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III
Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors
Cloning and characterization of two human polyspecific organic cation transporters
Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases
Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors
Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)
Cloning and expression in vitro of human xanthine dehydrogenase/oxidase
Cloning and expression of a cDNA encoding human sterol carrier protein 2
Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism
Cloning and expression of a cDNA for the human prostacyclin receptor
Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype
Cloning and expression of a cDNA for the human prostanoid FP receptor
Cloning and expression of a cDNA for the human prostanoid IP receptor
Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor
Cloning and expression of a human ATP-citrate lyase cDNA
Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine
Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens
Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells
Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter
Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
Cloning and expression of a human serotonin 5-HT4 receptor cDNA
Cloning and expression of a novel human brain Na+ channel
Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family
Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.
Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney
Cloning and expression of avian glutamine phosphoribosylpyrophosphate amidotransferase. Conservation of a bacterial propeptide sequence supports a role for posttranslational processing
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III)
Cloning and expression of cDNA for a human thromboxane A2 receptor
Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme
Cloning and expression of functional shikimate dehydrogenase (EC from Mycobacterium tuberculosis H37Rv
Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase
Cloning and expression of human aldose reductase
Cloning and expression of human apolipoprotein D cDNA
Cloning and expression of human arylsulfatase A
Cloning and expression of human core 1 beta1,3-galactosyltransferase
Cloning and expression of human deoxycytidine kinase cDNA
Cloning and expression of human deoxyguanosine kinase cDNA
Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins.
Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase
Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase
Cloning and expression of human liver dehydroepiandrosterone sulphotransferase
Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA
Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes
Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells
Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells
Cloning and expression of human uridine phosphorylase
Cloning and expression of mutations demonstrating intragenic complementation in mut0 methylmalonic aciduria
Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation
Cloning and expression of the cDNA for human antithrombin III
Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2
Cloning and expression of the gene involved in Sanfilippo B syndrome (mucopolysaccharidosis III B)
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes
Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence
Cloning and expression of the human N-acetylglutamate synthase gene
Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability
Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells
Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney
Cloning and functional characterization of a human A1 adenosine receptor
Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine
Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family
Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6)
Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.
Cloning and functional characterization of the human 5-HT2B serotonin receptor
Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine
Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2
Cloning and functional expression of a human eosinophil CC chemokine receptor
Cloning and functional expression of a human kidney Na+:HCO3- cotransporter
Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+)
Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type
Cloning and functional expression of a human parathyroid hormone receptor
Cloning and functional expression of a human uridine nucleotide receptor
Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY
Cloning and functional expression of a urea transporter from human bone marrow cells
Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta
Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene
Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx
Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae
Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor
Cloning and functional expression of the human histamine H3 receptor
Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
Cloning and gene expression of hexokinase I and II in the chicken skeletal muscle
Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin
Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis
Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase
Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2
Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria
Cloning and molecular analysis of the human citrate synthase gene
Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2
Cloning and mRNA tissue distribution of human PPARgamma coactivator-1
Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis
Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor
Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2
Cloning and recombinant expression of a structurally novel human secreted phospholipase A2
Cloning and recombinant expression of human group IIF-secreted phospholipase A(2)
Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid
Cloning and recombinant expression of rat and human kynureninase
Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor
Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin
Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle
Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor
Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor
Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue
Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis
Cloning and sequencing of human FSH receptor cDNA
Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
Cloning and sequencing of human LH/hCG receptor cDNA
Cloning and sequencing of the cDNA encoding human P5
Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues
Cloning and structural analysis of genomic DNA for human renal dipeptidase
Cloning and structural characterization of a human non-erythroid band 3-like protein
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family
Cloning and tissue distribution of the human G protein beta 5 cDNA.
Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin
Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli
Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet
Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin
Cloning of a gene fragment encoding chicken complement component C3d with expression and immunogenicity of Newcastle disease virus F gene-C3d fusion protein
Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant
Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy
Cloning of a human heptahelical receptor closely related to the P2Y5 receptor
Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter
Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs
Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
Cloning of a human renal p-aminohippurate transporter, hROAT1
Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family
Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains
Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein
Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis
Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype
Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85
Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues
Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter
Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase
Cloning of antizyme inhibitor, a highly homologous protein to ornithine decarboxylase
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors
Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors
Cloning of complementary DNA encoding a functional human interleukin-8 receptor
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction
Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite
Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus
Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2
Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3----p36.2
Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor
Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells
Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties
Cloning of novel kinectin splice variants with alternative C-termini: structure, distribution and evolution of mouse kinectin
Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells
Cloning of the cDNA and gene for a human D2 dopamine receptor
Cloning of the cDNA for human 12-lipoxygenase
Cloning of the cDNA for the human beta 1-adrenergic receptor
Cloning of the cDNAs encoding the cellular retinaldehyde-binding protein from bovine and human retina and comparison of the protein structures.
Cloning of the gamma chain of the human IL-2 receptor
Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily
Cloning of the human brain GABA transporter
Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient
Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1
Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line
Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes
Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1
Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site
Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C
Cloning of the human MCCA and MCCB genes and mutations therein reveal the molecular cause of 3-methylcrotonyl-CoA: carboxylase deficiency
Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2
Cloning of the human sodium lodide symporter
Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger
Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)
Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm)
Cloning of the sixth complement component and, spatial and temporal expression profile of MAC structural and regulatory genes in chicken
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line
Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome
Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations
Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B
Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP
Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor
Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct
Cloning, characterization, and chromosome mapping of the human GlcAT-S gene
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line
Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase
Cloning, characterization, and modeling of mouse and human guanylate kinases
Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene
Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2
Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor
Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins
Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV
Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase
Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
Cloning, expression, and chromosomal mapping of a human ganglioside sialidase
Cloning, expression, and fatty acid regulation of the human delta-5 desaturase
Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)
Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor
Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus
Cloning, expression, and properties of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
Cloning, expression, cellular distribution, and role in chemotaxis of a C5a receptor in rainbow trout: the first identification of a C5a receptor in a nonmammalian species
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms
Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype
Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor
Cloning, functional expression and tissue distribution of the human P2Y6 receptor
Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype
Cloning, genomic organization, and characterization of a human cholinephosphotransferase
Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase
Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)
Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)
Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase
Cloning, sequencing and functional expression of a novel human thioredoxin reductase
Cloning, sequencing, and expression of cDNA for human beta-galactosidase
Cloning, sequencing, and expression of cDNA for human beta-glucuronidase
Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2
Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3
Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3
Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney
Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family
Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact
Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon
Close homolog of L1 is an enhancer of integrin-mediated cell migration
Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex
Closed chromatin loops at the ends of chromosomes
Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
Clostridium botulinum toxins
Clues to the pathogenesis of familial colorectal cancer
Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane
Clustering of mutations in the biotin-binding region of holocarboxylase synthetase in biotin-responsive multiple carboxylase deficiency
Clustering of the high affinity Fc receptor for immunoglobulin G (Fc gamma RI) results in phosphorylation of its associated gamma-chain
Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases
CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18)
CNG and HCN channels: two peas, one pod
Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells
Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
Co-occurrence of three different mutations in the bilirubin UDP-glucuronosyltransferase gene in a Chinese family with Crigler-Najjar syndrome type I and Gilbert's syndrome
Co-operative Cdc42 and Rho signalling mediates ephrinB-triggered endothelial cell retraction
Co-translational membrane insertion of mitochondrially encoded proteins
CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution
Coacervation characteristics of recombinant human tropoelastin
Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin
Coacervation of tropoelastin
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Coactivator and promoter-selective properties of RNA polymerase I TAFs.
Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases
Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1
Coat proteins and vesicle budding
Coated pits, coated vesicles, and receptor-mediated endocytosis
Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex
Cochlear outer hair cell motility
Code for collagen's stability deciphered
Codeposition of apolipoprotein A-IV and transthyretin in senile systemic (ATTR) amyloidosis
Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons
Coenzyme A metabolism
Coenzyme A: back in action
Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency
Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel
Cofactor proteins in the assembly and expression of blood clotting enzyme complexes
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation
Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells
Cohesin component dynamics during meiotic prophase I in mammalian oocytes
Cohesin's DNA Exit Gate Is Distinct from Its Entrance Gate and Is Regulated by Acetylation
Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells.
Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II
COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair
Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage
Collagen cross-linking amino acids
Collagen cross-linking. Purification and substrate specificity of lysyl oxidase
Collagen cross-linking: lysyl oxidase dependent synthesis of pyridinoline in vitro: confirmation that pyridinoline is derived from collagen
Collagen Cross-Links
Collagen fibril form and function
Collagen fibril formation
Collagen fibrillogenesis in tendon development: current models and regulation of fibril assembly
Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
Collagen heterogeneity in human cartilage: identification of several new collagen chains
Collagen I and III and their decorin modified surfaces studied by atomic force microscopy and the elucidation of their affinity toward positive apolipoprotein B-100 residue by quartz crystal microbalance
Collagen IX
Collagen of articular cartilage
Collagen self-assembly and the development of tendon mechanical properties
Collagen structure and stability
Collagen triple-helix formation in all-trans chains proceeds by a nucleation/growth mechanism with a purely entropic barrier
Collagen type I and type V are present in the same fibril in the avian corneal stroma
Collagen type IX: evidence for covalent linkages to type II collagen in cartilage
Collagen VI, conformation of A-domain arrays and microfibril architecture
Collagen XI nucleates self-assembly and limits lateral growth of cartilage fibrils
Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains
Collagen XVI in health and disease
Collagen XVI is expressed by human dermal fibroblasts and keratinocytes and is associated with the microfibrillar apparatus in the upper papillary dermis
Collagen XVII
Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis
Collagen XXIV, a vertebrate fibrillar collagen with structural features of invertebrate collagens: selective expression in developing cornea and bone
Collagen XXVII organises the pericellular matrix in the growth plate
Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.
Collagen-induced platelet activation
Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis
Collagenase-1 complexes with alpha2-macroglobulin in the acute and chronic wound environments
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates
Collagenous transmembrane proteins: recent insights into biology and pathology
Collagens and collagen-related diseases
Collagens at a glance
Collagens, modifying enzymes and their mutations in humans, flies and worms
Collagens--structure, function, and biosynthesis
Collagens: molecular biology, diseases, and potentials for therapy
Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity
Collectins and ficolins: sugar pattern recognition molecules of the mammalian innate immune system
Collections and ficolins: humoral lectins of the innate immune defense
Colocalization of ferroportin-1 with hephaestin on the basolateral membrane of human intestinal absorptive cells
Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon
Colocalization of the homophilic binding site and the neuritogenic activity of the cell adhesion molecule L1 to its second Ig-like domain
Colorectal cancer and genetic alterations in the Wnt pathway
Colour vision deficiency
Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily
Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development
Combined methylmalonic aciduria and homocystinuria (cblC): phenotype-genotype correlations and ethnic-specific observations
Coming to grips with integrin binding to ligands
Common and distinct elements in cellular signaling via EGF and FGF receptors
Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Common themes in siRNA-mediated epigenetic silencing pathways
Common variations in ALG9 are not associated with bipolar I disorder: a family-based study
Communicating with Hedgehogs
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm
Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
Comparative analysis of human masculinity
Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts
Comparative analysis of MTF-1 binding sites between human and mouse
Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase
Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis
Comparative analysis of the distribution of laminin chains in the basement membranes in some malignant epithelial tumors: the alpha1 chain of laminin shows a selected expression pattern in human carcinomas
Comparative analysis of the efficacy of A1 adenosine receptor activation of Gi/o alpha G proteins following coexpression of receptor and G protein and expression of A1 adenosine receptor-Gi/o alpha fusion proteins
Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2
Comparative characterization of human and rat liver glycogen synthase
Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)
Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2
Comparative proteomic analysis identifies a role for SUMO in protein quality control
Comparative proteomics of clathrin-coated vesicles
Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency
Comparative study of the activity and composition of HDL3 in Russian and American men
Comparative study on the thermostability of collagen I of skin and bone: influence of posttranslational hydroxylation of prolyl and lysyl residues
Comparative transcriptional profiling of two human embryonic stem cell lines
Comparison of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and trioleoylglycerol/phosphatidylcholine-stabilized particles as substrates for lipoprotein lipase
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
Comparison of human B cell activation by TLR7 and TLR9 agonists
Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers
Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue
Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin
Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats
Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2
Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells
Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells
Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.
Comparison of the specificities of laminin, thrombospondin, and von Willebrand factor for binding to sulfated glycolipids
Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines
Compartmentalization of aquaporins in the human intestine
Compartmentalization of protein traffic in insulin-sensitive cells.
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles
Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes.
Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors
Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA.
Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes
Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation
Complement activation by apoptotic endothelial cells following hypoxia/reoxygenation
Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration
Complement C4bC2 complex formation: an investigation by surface plasmon resonance
Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells
Complement escape of human pathogenic bacteria by acquisition of complement regulators
Complement evasion by human pathogens
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
Complement fragment C3a controls mutual cell attraction during collective cell migration
Complement inhibition by human vitronectin involves non-heparin binding domains
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells
Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils
Complement regulators and inhibitory proteins
Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes
Complement-dependent clearance of apoptotic cells by human macrophages
Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity
Complement-opsonized IgG antibody/dsDNA immune complexes bind to CR1 clusters on isolated human erythrocytes
Complement: a critical test of its biological importance
Complement: a key system for immune surveillance and homeostasis
Complement: a unique innate immune sensor for danger signals
Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis
Complete amino acid sequence of human liver cytosolic alanine aminotransferase (GPT) determined by a combination of conventional and mass spectral methods
Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.
Complete amino acid sequence of human phosphoglycerate kinase. Isolation and amino acid sequence of tryptic peptides.
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid
Complete amino acid sequence of the medium-chain S-acyl fatty acid synthetase thio ester hydrolase from rat mammary gland
Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)
Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages
Complete primary structure and genomic organization of the mouse Col14a1 gene
Complete primary structure of a human plasma membrane Ca2+ pump
Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13
Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics
Complete sequencing and characterization of 21,243 full-length human cDNAs
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains
Completion of base excision repair by mammalian DNA ligases
Completion of mammalian lagging strand DNA replication using purified proteins.
Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication.
Complex formation and functional versatility of Mre11 of budding yeast in recombination
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region
Complex formation between metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes leads to a shift of the photoproduct equilibrium
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro
Complex genomic rearrangements lead to novel primate gene function
Complex III releases superoxide to both sides of the inner mitochondrial membrane
Complex phosphorylation dynamics control the composition of the Syk interactome in B cells
Complex regulation of the human gene for the Z-DNA binding protein DLM-1
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response
Complicated RNA splicing of chicken telomerase reverse transcriptase revealed by profiling cells both positive and negative for telomerase activity
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase
Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p
Components of coated vesicles and nuclear pore complexes share a common molecular architecture
Components of the collagen prolyl 3-hydroxylation complex are crucial for normal bone development
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes
Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds
Composition, recruitment and regulation of the PRC2 complex
Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice
Compound heterozygous mutations affect protein folding and function in patients with congenital sucrase-isomaltase deficiency
Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling
Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Comprehensive proteomic analysis of the human spliceosome.
Compressed microfibril models of the native collagen fibril
Computational approach for determining the spectrum of DNA damage induced by ionizing radiation.
Computational insights into the role of glutathione in oxidative stress
Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases
Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans
Concepts and principles of O-linked glycosylation
Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover
Concerted action of tenascin-C domains in cell adhesion, anti-adhesion and promotion of neurite outgrowth
Concerted action of two cation filters in the aquaporin water channel
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
Concerted evolution of human amylase genes
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
Condensation of rat telomere-specific nucleosomal arrays containing unusually short DNA repeats and histone H1
Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein
Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis
Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development
Confirmation of GPRA: a putative drug target for asthma
Conformation of beta 2-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond
Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic
Conformational rearrangements upon Syk auto-phosphorylation
Conformational transition associated with E1-E2 interaction in small ubiquitin-like modifications
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency: from birth to adulthood
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia
Congenital disorder of glycosylation IIa: the trouble with diagnosing a dysmorphic inborn error of metabolism
Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I
Congenital disorders of glycosylation
Congenital disorders of glycosylation (CDG): it's (nearly) all in it!
Congenital disorders of glycosylation IIa cause growth retardation, mental retardation, and facial dysmorphism
Congenital Disorders of Glycosylation Overview
Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase
Congenital disorders of glycosylation. Part I. Defects of protein N-glycosylation
Congenital disorders of glycosylation: a review
Congenital disorders of glycosylation: review of their molecular bases, clinical presentations and specific therapies
Congenital glutamine deficiency with glutamine synthetase mutations
Congenital heart disease caused by mutations in the transcription factor NKX2-5
Congenital hypothyroidism caused by a mutation in the Na+/I- symporter
Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis
Congenital myasthenic syndromes due to mutations in ALG2 and ALG14
Congenital sucrase-isomaltase deficiency arising from cleavage and secretion of a mutant form of the enzyme
Congenital sucrase-isomaltase deficiency because of an accumulation of the mutant enzyme in the endoplasmic reticulum
Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport block of sucrase-isomaltase in a pre-Golgi compartment
Congenital sucrase-isomaltase deficiency: heterogeneity of inheritance, trafficking, and function of an intestinal enzyme complex
Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450C18 gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients
Connections with connexins: the molecular basis of direct intercellular signaling
Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos
Connexin-43 hemichannels opened by metabolic inhibition
Connexin-specific distribution within gap junctions revealed in living cells
Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis
Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells
Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF
Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging
Conservation of the human telomere sequence (TTAGGG)n among vertebrates
Conserved and distinct aspects of the avian Toll-like receptor (TLR) system: implications for transmission and control of bird-borne zoonoses
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells
Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
Conserved domains of the class A scavenger receptors: evolution and function
Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling
Conserved initiator proteins in eukaryotes
Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation
Conserved roles of Sam50 and metaxins in VDAC biogenesis
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6
Conserved themes in small-RNA-mediated transposon control
Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome
Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas
Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I
Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
Constitutive and inducible expression and regulation of vascular endothelial growth factor
Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin
Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells
Constitutive nuclear import and stress-regulated nucleocytoplasmic shuttling of mammalian heat-shock factor 1
Constitutive receptor activation by Crouzon syndrome mutations in fibroblast growth factor receptor (FGFR)2 and FGFR2/Neu chimeras
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
Constructing inhibitory synapses
Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection
Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host
Construction of a model for the aggregation and cross-linking region (7S domain) of type IV collagen based upon an evaluation of the primary structure of the alpha 1 and alpha 2 chains in this region
Contacts between mammalian mitochondrial translational initiation factor 3 and ribosomal proteins in the small subunit
Context-dependent regulation of Groucho/TLE-mediated repression
Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle
Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C
Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation
Contribution of globular death domains and unstructured linkers to MyD88.IRAK-4 heterodimer formation: an explanation for the antagonistic activity of MyD88s
Contribution of the Haldane effect to the increase in arterial carbon dioxide tension in hypoxaemic subjects treated with oxygen
Contributions of proteomics to understanding phagosome maturation
Contributions of the extracellular and cytoplasmic domains of platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) in regulating cell-cell localization
Contributions of the LG modules and furin processing to laminin-2 functions
Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding
Contributions of two nuclear localization signals of influenza A virus nucleoprotein to viral replication
Control of axonal branching and synapse formation by focal adhesion kinase
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2
Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs
Control of cross-over by single-strand DNA resection.
Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain
Control of elongation by RNA polymerase II.
Control of endodermal endocrine development by Hes-1
Control of extracellular matrix assembly by syndecan-2 proteoglycan
Control of glycaemia
Control of ground-state pluripotency by allelic regulation of Nanog
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Control of human telomere length by TRF1 and TRF2
Control of influenza virus gene expression: quantitative analysis of each viral RNA species in infected cells
Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells
Control of light-sensitive current in salamander rods
Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation
Control of matrix metalloproteinase catalytic activity
Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C
Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
Control of mRNA decay by phosphorylation of tristetraprolin
Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen
Control of Nuclear Activities by Substrate-Selective and Protein-Group SUMOylation
Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymus-associated core 2 beta1, 6-n-acetylglucosaminyltransferase
Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
Control of promatrilysin (MMP7) activation and substrate-specific activity by sulfated glycosaminoglycans
Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification
Control of the amplification convertase of complement by the plasma protein beta1H
Control of the assembly of ATP- and ADP-actin by formins and profilin
Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR
Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor
Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase
Control of the senescence-associated secretory phenotype by NF-?B promotes senescence and enhances chemosensitivity
Control of translation and mRNA degradation by miRNAs and siRNAs
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
Controlling influenza by inhibiting the virus's neuraminidase
Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²? methylation by human polycomb repressive complex 2 and vSET
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women
Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution
Conversion of diphosphatidylglycerol to bis(monoacylglyceryl)phosphate by lysosomes
Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes
Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage
Conversion of Phosphatidylcholine to Phosphatidylglycerol with Phospholipase D and glycerol
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
Conversion of the amino acid sequence gly-pro-pro in protein to gly-pro-hyp by collagen proline hydroxylase
Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
Cooperation of translocase complexes in mitochondrial protein import
Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads
Cooperative interaction of human HSF1 heat shock transcription factor with promoter DNA
Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding
Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells
Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
Coordinated histone modifications mediated by a CtBP co-repressor complex
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains
Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex
Coordinating TLR-activated signaling pathways in cells of the immune system
Coordination between the polymerase and 5'-nuclease components of DNA polymerase I of Escherichia coli.
Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner
Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha
Coordination of Rab8 and Rab11 in primary ciliogenesis
Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription
COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites
COPII-mediated vesicle formation at a glance
Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins
Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
Core exosome-independent roles for Rrp6 in cell cycle progression
Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex
Core structure of gp41 from the HIV envelope glycoprotein
Core transcriptional regulatory circuitry in human embryonic stem cells
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype
Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells
Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins
CoREST represses the heat shock response mediated by HSF1
CoREST: a functional corepressor required for regulation of neural-specific gene expression
Correct integration of retroviral DNA in vitro
Correlation between subunit interactions and enzymatic activity of phosphorylase a. Method for determining equilibrium constants from initial rate measurements
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Cotranslational folding and calnexin binding during glycoprotein synthesis
Counts of influenza virus particles
COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis
Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein
Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death
Coupling morphogenesis to mitotic entry
Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling
Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells
Coupling of the TCR to integrin activation by Slap-130/Fyb
Coupling RNA polymerase II transcription with pre-mRNA processing.
Covalent association of C3b with C4b within C5 convertase of the classical complement pathway
Covalent binding properties of the human complement protein C4 and hydrolysis rate of the internal thioester upon activation
Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage
Covalent modification of PML by the sentrin family of ubiquitin-like proteins
CP110 and its network of partners coordinately regulate cilia assembly
CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease
CpG motifs in bacterial DNA trigger direct B-cell activation
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
CpG-ODN-induced nitric oxide production is mediated through clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-kappaB pathways in avian macrophage cells (HD11)
cPLA2 is phosphorylated and activated by MAP kinase
CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family
CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide
Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid
Craniosynostosis associated with FGFR3 pro250arg mutation results in a range of clinical presentations including unisutural sporadic craniosynostosis
CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling
CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression
Creatine and creatinine metabolism
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
CREB is a regulatory target for the protein kinase Akt/PKB
Crigler-Najjar syndrome type I in Tunisia may be associated with a founder effect related to the Q357R mutation within the UGT1 gene
Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells
Cripto-1 is a cell surface marker for a tumorigenic, undifferentiated subpopulation in human embryonal carcinoma cells
Cripto-1: an embryonic gene that promotes tumorigenesis
Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
Critical residues of alphaX I-domain recognizing fibrinogen central domain
Critical role for chicken Rad17 and Rad9 in the cellular response to DNA damage and stalled DNA replication
Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade
Critical role for Gab2 in transformation by BCR/ABL
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation
Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development
Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha
Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells
Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes
Critical role of STAT3 in leptin's metabolic actions
Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1
Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion
Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
Crk activation of JNK via C3G and R-Ras
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis
CRM1 is an export receptor for leucine-rich nuclear export signals
CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
Cross talk among TGF-? signaling pathways, integrins, and the extracellular matrix
Cross Talk between Signaling and Vitamin A Transport by the Retinol-Binding Protein Receptor STRA6
Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
Cross-linking and the molecular packing of corneal collagen
Cross-linking in collagen and elastin
Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase
Cross-linking of collagen and elastin. Properties of lysyl oxidase
Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase
Cross-links between Fanconi anaemia and BRCA2
Cross-presentation by intercellular peptide transfer through gap junctions
Cross-presentation: avoiding trafficking chaos?
Cross-presentation: underlying mechanisms and role in immune surveillance
Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase
Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules
Cross-talk between the insulin and angiotensin signaling systems
Crossing over analysis at pachytene in man
Crosslinking of CD66B on peripheral blood neutrophils mediates the release of interleukin-8 from intracellular storage
Crosstalk between apoptosis, necrosis and autophagy
Crosstalk of Arf and Rab GTPases en route to cilia
Crosstalk pathways between Toll-like receptors and the complement system
CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta
Crucial role of conserved cysteine residues in the assembly of two iron-sulfur clusters on the CIA protein Nar1
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
Cruising along microtubule highways: how membranes move through the secretory pathway
Cry1 circadian phase in vitro: wrapped up with an E-box
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly
Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1
Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome
Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis
Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXRalpha-Regulated and CLOCK/BMAL1-Regulated Systems
Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression
Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5
Crystal structure and mechanism of activation of TANK-binding kinase 1
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator
Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
Crystal structure and site 1 binding energetics of human placental lactogen
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
Crystal structure of a beta-catenin/BCL9/Tcf4 complex
Crystal structure of a beta-catenin/Tcf complex
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis
Crystal structure of a coiled-coil domain from human ROCK I
Crystal structure of a complex between anthrax toxin and its host cell receptor
Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor
Crystal structure of a covalent intermediate of endogenous human arylsulfatase A
Crystal structure of a dimeric oxidized form of human peroxiredoxin 5
Crystal structure of a full-length beta-catenin
Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision
Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
Crystal structure of a human mitochondrial deoxyribonuclease
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling
Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1
Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
Crystal structure of an Eph receptor-ephrin complex
Crystal structure of an HIV-binding recombinant fragment of human CD4
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent
Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Crystal structure of an open conformation of citrate synthase from chicken heart at 2.8-A resolution
Crystal structure of botulinum neurotoxin type A and implications for toxicity
Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex
Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules
Crystal Structure of Clostridium botulinum Whole Hemagglutinin Reveals a Huge Triskelion-shaped Molecular Complex
Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization
Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
Crystal structure of Homo sapiens protein LOC79017
Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics
Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response
Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis
Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease
Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity
Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site
Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring
Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations
Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity
Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes
Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP
Crystal structure of human homogentisate dioxygenase.
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.
Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase
Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution
Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain
Crystal structure of human kynurenine aminotransferase I
Crystal structure of human kynurenine aminotransferase II
Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia
Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution
Crystal structure of human prostaglandin F synthase (AKR1C3)
Crystal structure of human protein tyrosine phosphatase 1B
Crystal structure of human pyrroline-5-carboxylate reductase
Crystal structure of human recombinant ornithine aminotransferase
Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis
Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1
Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation
Crystal structure of human synbindin reveals two conformations of longin domain
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition
Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A
Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity
Crystal structure of human uroporphyrinogen decarboxylase
Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein
Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis
Crystal structure of IRF-3 in complex with CBP
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity
Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition
Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2
Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism
Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications
Crystal structure of Rac1 bound to its effector phospholipase C-beta2
Crystal structure of SUMO-3-modified thymine-DNA glycosylase
Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation
Crystal structure of the anthrax toxin protective antigen
Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector
Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin
Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS
Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA
Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer
Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
Crystal structure of the Formin mDia1 in autoinhibited conformation
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation
Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex
Crystal structure of the hexamer of human heat shock factor binding protein 1
Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form.
Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling
Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)
Crystal structure of the human PRMT5:MEP50 complex
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)
Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller
Crystal structure of the motor domain of the kinesin-related motor ncd
Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma
Crystal structure of the nucleosome core particle at 2.8 A resolution
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule
Crystal structure of thymine DNA glycosylase conjugated to SUMO-1
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture
Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding
Crystal structures of human alpha-defensins HNP4, HD5, and HD6
Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction
Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex
Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping
Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1)
Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms
Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly
Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design
Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences
Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design
Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2
Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Crystalline D-glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle
Crystallization and properties of human liver ornithine aminotransferase
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis
Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation
CSK: a protein-tyrosine kinase involved in regulation of src family kinases
CTNS mutations in patients with cystinosis
Cu(I) affinities of the domain 1 and 3 sites in the human metallochaperone for Cu,Zn-superoxide dismutase
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)
Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin
Cullin 4A associates with the UV-damaged DNA-binding protein DDB
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family
Cumulative mutations of ubiquitin acceptor sites in human immunodeficiency virus type 1 gag cause a late budding defect
Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function
Current insights into the formation and breakdown of hemidesmosomes
Current knowledge of the large RhoGAP family of proteins
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that
Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)
Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
Cutting edge: Identification of a hybrid cytokine consisting of IL-7 and the beta-chain of the hepatocyte growth factor/scatter factor
Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1
Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK
Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6
Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells
Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells
Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)
Cutting edge: TREM-2 attenuates macrophage activation
Cyclic AMP raises intracellular Ca(2+) in human megakaryocytes independent of protein kinase A
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of the corresponding cDNA.
Cyclic GMP phosphodiesterase from cattle retina. Amino acid sequence of the gamma-subunit and nucleotide sequence of the corresponding cDNA.
Cyclic GMP phosphodiesterase-5: target of sildenafil
Cyclic GMP synthesis and function
Cyclic GMP-activated conductance of retinal photoreceptor cells
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
Cyclic GMP-dependent protein kinase activates cloned BKCa channels expressed in mammalian cells by direct phosphorylation at serine 1072
Cyclic GMP-gated channels of bovine rod photoreceptors: affinity, density and stoichiometry of Ca(2+)-calmodulin binding sites.
Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes
Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system
Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets
Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate
Cyclic nucleotides and phosphodiesterases in platelets
Cyclic [G(2',5')pA(3',5')p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
Cyclin A is required at two points in the human cell cycle
Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma
Cyclin-dependent kinases and S phase control in mammalian cells
Cycling to cancer with cyclin D1
Cyclooxygenases: structural, cellular, and molecular biology
Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2
Cyclopentenone prostaglandins: new insights on biological activities and cellular targets
Cyclosporin-A sensitive induction of NF-AT in murine B cells
CYLD deubiquitinates RIP1 in the TNF?-induced necrosome to facilitate kinase activation and programmed necrosis
CYP11B1 mutations causing congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids
CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer
CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5
Cysteine cathepsins S and L modulate anti-angiogenic activities of human endostatin
Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: evidence for an alternative cysteine biosynthesis pathway in mycobacteria
Cysteine-to-serine mutants of the human copper chaperone for superoxide dismutase reveal a copper cluster at a domain III dimer interface
Cysteinyl leukotriene receptors
Cystin localizes to primary cilia via membrane microdomains and a targeting motif
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes
Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochrome P450 enzymes: central players in cardiovascular health and disease
Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite
Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions
Cytochrome P450s and cholesterol homeostasis
Cytochrome P450s and other enzymes in drug metabolism and toxicity
Cytochrome P450s in the regulation of cellular retinoic acid metabolism
Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism
Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes
Cytochromes p450: roles in diseases
Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation
Cytokine receptors and signal transduction
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
Cytokine-driven cell cycling is mediated through Cdc25A
Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain
Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
Cytokines and chemokines in autoimmune disease: an overview
Cytoplasmic 5'(3')-nucleotidase from human placenta
Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor
Cytoplasmic chaperonin containing TCP-1: structural and functional characterization
Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells
Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions
Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V
Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines
Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation
Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site.
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus
Cytoplasmic STAT proteins associate prior to activation
Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins
Cytosine methylation: remaining faithful
Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers
Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism
Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation
Cytosolic phospholipase A2 is phosphorylated in collagen- and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase
Cytosolic Sensing of Viruses
Cytotoxic effects of kainate ligands on HEK cell lines expressing recombinant kainate receptors
Cytotoxic T-lymphocyte antigen-4 and programmed death-1 function as negative regulators of lymphocyte activation
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p
D-2-hydroxyglutaric acidaemia: identification of a new enzyme, D-2-hydroxyglutarate dehydrogenase, localized in mitochondria
D-2-Hydroxyglutaric aciduria: unravelling the biochemical pathway and the genetic defect
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
DANCE/fibulin-5 promotes elastic fiber formation in a tropoelastin isoform-dependent manner
DAP10- and DAP12-associated receptors in innate immunity
DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase
Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation
Dark adaptation and the retinoid cycle of vision
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
DARPP-32: an