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NAT2 acetylation Stable identifier REACT_6944.2 Reviewed D'Eustachio, P, 2008-05-28 Your feedback Let us know what you think of this article (click here) Typical NAT 2 substrates were chosen as examples. They are paraxanthine, isoniazid and N-hydroxy 4-aminobiphenyl. Input (present at start of reaction) NAT2 substrate [cytosol] Acyl-NAT2 intermediate [cytosol] UKEGBCdORHUR Output (present at end of reaction) NAT2 acetylated conjugate [cytosol] NAT2 [cytosol] UKEGBCdORHUR Catalyst Acyl-NAT2 intermediate [cytosol] UKEGBCdORHUR GO molecular function arylamine N-acetyltransferase activity GO Preceding event(s) The acetyl group from acetyl-CoA is transferred to the NAT2 [Homo sapiens] Following event(s) The acetyl group from acetyl-CoA is transferred to the NAT2 [Homo sapiens] Organism Homo sapiens Cellular compartment cytosol GO Equivalent event(s) in other organism(s) NAT2 acetylation [Bos taurus] NAT2 acetylation [Sus scrofa] NAT2 acetylation [Mus musculus] NAT2 acetylation [Rattus norvegicus] NAT2 acetylation [Gallus gallus] NAT2 acetylation [Taeniopygia guttata] NAT2 acetylation [Danio rerio] NAT2 acetylation [Escherichia coli] NAT2 acetylation [Mycobacterium tuberculosis] NAT2 acetylation [Staphylococcus aureus N315] Participating molecules 5-acetylamino-6-formylamino-3-methyluracil [cytosol] CP Acyl-NAT2 intermediate [cytosol] UKEGBCdORHUR Isoniazid [cytosol] CCP N-acetylisoniazid [cytosol] CCP N-Hydroxy-4-aminobiphenyl [cytosol] CCP N-hydroxy-4-aminobiphenyl O-acetylated conjugate [cytosol] C NAT2 [cytosol] UKEGBCdORHUR NAT2 acetylated conjugate [cytosol] NAT2 substrate [cytosol] Paraxanthine [cytosol] CP