Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways reviewed by Leppla, Stephen H (5205698)

DB_ID Name
5210891 Uptake and function of anthrax toxins

Details on Person Leppla, Stephen H

_displayNameLeppla, Stephen H
_timestamp2017-08-22 20:45:31
affiliation[Affiliation:5490364] National Institutes of Health,National Institute of Allergy and Infectious Diseases
created[InstanceEdit:5205725] D'Eustachio, Peter, 2013-12-05
firstnameStephen H
modified[InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19
(author)[LiteratureReference:874007] Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
[LiteratureReference:5205695] Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase
[LiteratureReference:5205696] Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
[LiteratureReference:5205714] Crystal structure of the anthrax toxin protective antigen
[LiteratureReference:5205729] Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
[LiteratureReference:5209988] Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization
[LiteratureReference:5209992] Crystal structure of a complex between anthrax toxin and its host cell receptor
[LiteratureReference:5210014] The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin
[LiteratureReference:5211226] Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells
[LiteratureReference:5211331] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
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