Reactome: A Curated Pathway Database

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Pathways authored by Kikuchi, Akira (4640987)

DB_ID Name
5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins

Pathways reviewed by Kikuchi, Akira (4640987)

DB_ID Name
201681 TCF dependent signaling in response to WNT
201688 WNT mediated activation of DVL
201722 Formation of the beta-catenin:TCF transactivating complex
4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
4641263 Regulation of FZD by ubiquitination
4641258 Degradation of DVL
4641257 Degradation of AXIN
3769402 Deactivation of the beta-catenin transactivating complex
3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Details on Person Kikuchi, Akira

_displayNameKikuchi, Akira
_timestamp2017-08-22 20:41:59
created[InstanceEdit:4640988] Rothfels, K, 2013-09-27
modified[InstanceEdit:5246641] Rothfels, K, 2014-01-22
(author)[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
[LiteratureReference:4641122] Modulation of Wnt signaling by Axin and Axil
[LiteratureReference:5246628] Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
[LiteratureReference:5368397] A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation
[LiteratureReference:5368401] Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin
[LiteratureReference:5368408] Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway
[LiteratureReference:5368409] Inhibition of Wnt signaling pathway by a novel axin-binding protein
[LiteratureReference:5368411] Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein
[LiteratureReference:5368413] LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse
[LiteratureReference:5368418] The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility
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