Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways reviewed by Kalderon, D (207189)

DB_ID Name
209159 Assembly of the CI containing complexes
209190 Phosphorylation of CI
209214 Phosphorylation of SMO
209338 Assembly of the 'signalling complexes'
209360 Ubiquitination and proteolysis of phosphorylated CI
209392 Hedgehog pathway
209446 N-HH ligand not bound to PTC receptor complex
209452 N-HH ligand bound to PTC receptor complex
209471 Formation and transport of the N-HH ligand
216119 Activation of CI
216167 Nuclear CI is degraded
216217 Activation of SMO

Details on Person Kalderon, D

_displayNameKalderon, D
_timestamp2017-08-22 20:38:59
created[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
(author)[LiteratureReference:208220] The mechanism of hedgehog signal transduction
[LiteratureReference:208279] Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
[LiteratureReference:208328] Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb
[LiteratureReference:208388] Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
[LiteratureReference:216194] Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A
[LiteratureReference:216205] Hedgehog signaling: a smoothened conformational switch
[LiteratureReference:216277] Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
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