Reactome: A Curated Pathway Database

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Pathways reviewed by Overall, CM (189089)

DB_ID Name
1592389 Activation of Matrix Metalloproteinases

Details on Person Overall, CM

Class:IdPerson:189089
_displayNameOverall, CM
_timestamp2017-08-22 20:38:29
created[InstanceEdit:189008] D'Eustachio, P, 2006-11-03 14:39:28
firstnameChristopher M
initialCM
surnameOverall
(author)[InstanceEdit:2157511] Overall, CM, 2012-02-28
[LiteratureReference:188992] Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques
[LiteratureReference:1458428] TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains
[LiteratureReference:2157477] Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics
[LiteratureReference:2157483] Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
[LiteratureReference:2157484] Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase
[LiteratureReference:2157487] Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2
[LiteratureReference:2157493] Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage
[LiteratureReference:2157495] Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain
[LiteratureReference:2157500] Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway
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