Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways reviewed by Peters, JM (174234)

DB_ID Name
141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
141430 Inactivation of APC/C via direct inhibition of the APC/C complex
174048 APC/C:Cdc20 mediated degradation of Cyclin B
174084 Autodegradation of Cdh1 by Cdh1:APC/C
174113 SCF-beta-TrCP mediated degradation of Emi1
174143 APC/C-mediated degradation of cell cycle proteins
174154 APC/C:Cdc20 mediated degradation of Securin
174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
176408 Regulation of APC/C activators between G1/S and early anaphase
176409 APC/C:Cdc20 mediated degradation of mitotic proteins
176412 Phosphorylation of the APC/C
176417 Phosphorylation of Emi1
176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
179409 APC-Cdc20 mediated degradation of Nek2A

Details on Person Peters, JM

_displayNamePeters, JM
_timestamp2017-08-22 20:38:12
created[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
(author)[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
[InstanceEdit:188369] Peters, JM, 2006-10-10 10:07:26
[LiteratureReference:174065] Mitotic regulation of the human anaphase-promoting complex by phosphorylation
[LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
[LiteratureReference:174096] Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
[LiteratureReference:174165] The anaphase-promoting complex: proteolysis in mitosis and beyond
[LiteratureReference:174194] Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
[LiteratureReference:174245] Mitotic regulation of the APC activator proteins CDC20 and CDH1
[LiteratureReference:176424] How APC/C orders destruction
[LiteratureReference:176919] Splitting the chromosome: cutting the ties that bind sister chromatids
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