Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways authored by D'Eustachio, Peter (140934)

DB_ID Name
5250982 Toxicity of tetanus toxin (TeNT)
2160456 Phenylketonuria
2161517 Abacavir transmembrane transport
2161522 Abacavir transport and metabolism
2161541 Abacavir metabolism
70350 Fructose catabolism
70635 Urea cycle
70688 Proline catabolism
70895 Branched-chain amino acid catabolism
70921 Histidine catabolism
71064 Lysine catabolism
71182 Phenylalanine and tyrosine catabolism
71240 Tryptophan catabolism
71291 Metabolism of amino acids and derivatives
71387 Metabolism of carbohydrates
71406 Pyruvate metabolism and Citric Acid (TCA) cycle
71737 Pyrophosphate hydrolysis
73843 5-Phosphoribose 1-diphosphate biosynthesis
74160 Gene expression (Transcription)
75896 Plasmalogen biosynthesis
3229121 Glycogen storage diseases
3229133 Glycogen storage disease type Ib (SLC37A4)
83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
5336415 Uptake and function of diphtheria toxin
109582 Hemostasis
5357572 Lysosomal glycogen catabolism
5357609 Glycogen storage disease type II (GAA)
5358493 Synthesis of diphthamide-EEF2
3274531 Glycogen storage disease type Ia (G6PC)
3282872 Severe congenital neutropenia type 4 (G6PC3)
140834 Extrinsic Pathway of Fibrin Clot Formation
140837 Intrinsic Pathway of Fibrin Clot Formation
140875 Common Pathway of Fibrin Clot Formation
140877 Formation of Fibrin Clot (Clotting Cascade)
159740 Gamma-carboxylation of protein precursors
159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins
159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
162587 HIV Life Cycle
162589 Reverse Transcription of HIV RNA
162594 Early Phase of HIV Life Cycle
162592 Integration of provirus
162710 Synthesis of glycosylphosphatidylinositol (GPI)
162791 Attachment of GPI anchor to uPAR
162906 HIV Infection
163560 Triglyceride catabolism
163685 Integration of energy metabolism
163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
164378 PKA activation in glucagon signalling
164516 Minus-strand DNA synthesis
164525 Plus-strand DNA synthesis
164843 2-LTR circle formation
168179 Toll Like Receptor TLR1:TLR2 Cascade
168188 Toll Like Receptor TLR6:TLR2 Cascade
174824 Plasma lipoprotein assembly, remodeling, and clearance
175567 Integration of viral DNA into host genomic DNA
177539 Autointegration results in viral DNA circles
181438 Toll Like Receptor 2 (TLR2) Cascade
189085 Digestion of dietary carbohydrate
189200 Cellular hexose transport
189451 Heme biosynthesis
192456 Digestion of dietary lipid
193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
199220 Vitamin B5 (pantothenate) metabolism
2393930 Phosphate bond hydrolysis by NUDT proteins
352230 Amino acid transport across the plasma membrane
352832 Glucose transport
352875 Gluconeogenesis
352882 Glycolysis
353098 Carbohydrate metabolism
372442 Lipid metabolism
372568 Amino acid metabolism
372987 The tricarboxylic acid cycle
373920 Pyruvate metabolism
379716 Cytosolic tRNA aminoacylation
379724 tRNA Aminoacylation
379726 Mitochondrial tRNA aminoacylation
1428517 The citric acid (TCA) cycle and respiratory electron transport
389542 NADPH regeneration
389599 Alpha-oxidation of phytanate
389661 Glyoxylate metabolism and glycine degradation
389887 Beta-oxidation of pristanoyl-CoA
390247 Beta-oxidation of very long chain fatty acids
390918 Peroxisomal lipid metabolism
5652084 Fructose metabolism
5652227 Fructose biosynthesis
5657562 Essential fructosuria
5657560 Hereditary fructose intolerance
5659898 Intestinal saccharidase deficiencies
5659996 RPIA deficiency: failed conversion of R5P to RU5P
5661270 Catabolism of glucuronate to xylulose-5-phosphate
5662853 Essential pentosuria
428157 Sphingolipid metabolism
8848584 Wax biosynthesis
6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
499943 Interconversion of nucleotide di- and triphosphates
6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
6791461 RPIA deficiency: failed conversion of RU5P to R5P
6791465 Pentose phosphate pathway disease
500753 Pyrimidine biosynthesis
6806667 Metabolism of fat-soluble vitamins
6806664 Metabolism of vitamin K
6807047 Cholesterol biosynthesis via desmosterol
6807062 Cholesterol biosynthesis via lathosterol
6814848 Glycerophospholipid catabolism
556833 Metabolism of lipids
8953854 Metabolism of RNA
8953897 Cellular responses to external stimuli
8955332 Carboxyterminal post-translational modifications of tubulin
8963676 Intestinal absorption
8963678 Intestinal lipid absorption
8964011 HDL clearance
8964026 Chylomicron clearance
8964041 LDL remodeling
8964038 LDL clearance
8964058 HDL remodeling
8963896 HDL assembly
8963898 Plasma lipoprotein assembly
8963899 Plasma lipoprotein remodeling
8963901 Chylomicron remodeling
8963888 Chylomicron assembly
8978868 Fatty acid metabolism
8978934 Metabolism of cofactors
8979227 Triglyceride metabolism
8981373 Intestinal hexose absorption
597592 Post-translational protein modification
1660661 Sphingolipid de novo biosynthesis
3785653 Myoclonic epilepsy of Lafora
3814836 Glycogen storage disease type XV (GYG1)
3828062 Glycogen storage disease type 0 (muscle GYS1)
3858516 Glycogen storage disease type 0 (liver GYS2)
3878781 Glycogen storage disease type IV (GBE1)
880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
2028269 Signaling by Hippo
2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
5210891 Uptake and function of anthrax toxins

Pathways reviewed by D'Eustachio, Peter (140934)

DB_ID Name
5260271 Diseases of Immune System
2132263 Creation of classical C3 convertase
2132267 Formation of membrane attack complex (MAC)
2132270 Lectin-mediated initiation of complement cascade
2132273 Formation of membrane-bound convertase C3
2132281 Regulation of complement cascades
2132285 Complement Cascade
2132286 Classical antibody-mediated complement activation
2132287 Creation of alternative pathway C3 convertase
2132293 Formation of fluid-phase convertase C3
2142845 Hyaluronan metabolism
2142850 Hyaluronan biosynthesis and export
2160916 Hyaluronan uptake and degradation
75109 Triglyceride biosynthesis
75876 Synthesis of very long-chain fatty acyl-CoAs
2173345 Anaphylatoxins initiate inflammatory responses
2179392 EGFR Transactivation by Gastrin
3248023 Regulation by TREX1
3249367 STAT6-mediated induction of chemokines
3270619 IRF3-mediated induction of type I IFN
140179 Amine Oxidase reactions
140180 COX reactions
141334 PAOs oxidise polyamines to amines
141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
156590 Glutathione conjugation
159418 Recycling of bile acids and salts
163560 Triglyceride catabolism
2262752 Cellular responses to stress
2262749 Cellular response to hypoxia
166658 Complement cascade
166662 Lectin pathway of complement activation
166663 Initial triggering of complement
166665 Terminal pathway of complement
166786 Creation of C4 and C2 activators
168179 Toll Like Receptor TLR1:TLR2 Cascade
168188 Toll Like Receptor TLR6:TLR2 Cascade
168256 Immune System
168898 Toll-Like Receptors Cascades
173623 Classical antibody-mediated complement activation
173736 Alternative complement activation
174403 Glutathione synthesis and recycling
174577 Activation of C3 and C5
5423646 Aflatoxin activation and detoxification
181438 Toll Like Receptor 2 (TLR2) Cascade
187630 Arginine metabolism
1237112 Methionine salvage pathway
191273 Cholesterol biosynthesis
192105 Synthesis of bile acids and bile salts
193048 Androgen biosynthesis
193144 Estrogen biosynthesis
193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
193993 Mineralocorticoid biosynthesis
194002 Glucocorticoid biosynthesis
194068 Bile acid and bile salt metabolism
196071 Metabolism of steroid hormones
196108 Pregnenolone biosynthesis
196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
196783 Coenzyme A biosynthesis
196791 Vitamin D (calciferol) metabolism
200425 Import of palmitoyl-CoA into the mitochondrial matrix
204174 Regulation of pyruvate dehydrogenase (PDH) complex
209776 Amine-derived hormones
209822 Glycoprotein hormones
209905 Catecholamine biosynthesis
209931 Serotonin and melatonin biosynthesis
209943 Steroid hormones
209952 Peptide hormone biosynthesis
209968 Thyroxine biosynthesis
211859 Biological oxidations
211897 Cytochrome P450 - arranged by substrate type
211916 Vitamins
211935 Fatty acids
211945 Phase I - Functionalization of compounds
211958 Miscellaneous substrates
211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2
211979 Eicosanoids
211976 Endogenous sterols
211981 Xenobiotics
211994 Sterols are 12-hydroxylated by CYP8B1
211999 CYP2E1 reactions
217271 FMO oxidises nucleophiles
1268020 Mitochondrial protein import
264876 Insulin processing
1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
1369007 Mitochondrial ABC transporters
1369062 ABC transporters in lipid homeostasis
2422406 Innate Immune System
350562 Regulation of ornithine decarboxylase (ODC)
350864 Regulation of thyroid hormone activity
351143 Agmatine biosynthesis
351200 Interconversion of polyamines
351202 Metabolism of polyamines
5602415 UNC93B1 deficiency - HSE
5602410 TLR3 deficiency - HSE
5602358 Diseases associated with the TLR signaling cascade
5602498 MyD88 deficiency (TLR2/4)
5602636 IKBKB deficiency causes SCID
5602680 MyD88 deficiency (TLR5)
5602566 TICAM1 deficiency - HSE
5602571 TRAF3 deficiency - HSE
5603029 IkBA variant leads to EDA-ID
5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
5603037 IRAK4 deficiency (TLR5)
5603041 IRAK4 deficiency (TLR2/4)
373080 Class B/2 (Secretin family receptors)
375281 Hormone ligand-binding receptors
375280 Amine ligand-binding receptors
380095 Tachykinin receptors bind tachykinins
380994 ATF4 activates genes
381038 XBP1(S) activates chaperone genes
381033 ATF6 (ATF6-alpha) activates chaperones
381042 PERK regulates gene expression
381070 IRE1alpha activates chaperones
381119 Unfolded Protein Response (UPR)
381183 ATF6 (ATF6-alpha) activates chaperone genes
381340 Transcriptional regulation of white adipocyte differentiation
381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
382556 ABC-family proteins mediated transport
388479 Vasopressin-like receptors
389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
390648 Muscarinic acetylcholine receptors
390651 Dopamine receptors
390650 Histamine receptors
390666 Serotonin receptors
390696 Adrenoceptors
391903 Eicosanoid ligand-binding receptors
391908 Prostanoid ligand receptors
391906 Leukotriene receptors
400042 Adrenaline,noradrenaline inhibits insulin secretion
400253 Circadian Clock
417957 P2Y receptors
417973 Adenosine P1 receptors
418038 Nucleotide-like (purinergic) receptors
419408 Lysosphingolipid and LPA receptors
419771 Opsins
419812 Calcitonin-like ligand receptors
420092 Glucagon-type ligand receptors
420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
422356 Regulation of insulin secretion
1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
1474228 Degradation of the extracellular matrix
1474244 Extracellular matrix organization
433819 Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK
433835 IKK related kinases bound to dsRNA:TLR3:TICAM1 activate IRF3
433871 TRAF6 mediated induction of the anti inflammatory cytokines
434001 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
434048 TLR3 cascade
434131 NFkB activation mediated by RIP1 complexed with activated TLR3
434136 Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1
1483257 Phospholipid metabolism
437980 Activated TAK1 mediates p38 MAP kinase phosphorylation
437986 Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
437987 Toll-like receptors (TLR) cascades
5683826 Surfactant metabolism
5686938 Regulation of TLR by endogenous ligand
444209 Free fatty acid receptors
444473 Formyl peptide receptors bind formyl peptides and many other ligands
5687583 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)
5687613 Diseases associated with surfactant metabolism
444821 Relaxin receptors
5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)
5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
5688399 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)
5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
451524 MAPK activation in TLR cascade
8849175 Threonine catabolism
8852405 Signaling by MST1
8853383 Lysosomal oligosaccharide catabolism
8863678 Neurodegenerative Diseases
8866376 Reelin signalling pathway
8866423 VLDL assembly
8866427 VLDLR internalisation and degradation
8877627 Vitamin E
6783984 Glycine degradation
6787639 GDP-fucose biosynthesis
500792 GPCR ligand binding
6798163 Choline catabolism
8935690 Digestion
8937144 Aryl hydrocarbon receptor signalling
8942233 Intestinal infectious diseases
1606322 ZBP1(DAI) mediated induction of type I IFNs
1606341 IRF3 mediated activation of type 1 IFN
8953897 Cellular responses to external stimuli
1614517 Sulfide oxidation to sulfate
1614558 Degradation of cysteine and homocysteine
1614603 Cysteine formation from homocysteine
1614635 Sulfur amino acid metabolism
8963743 Digestion and absorption
8964046 VLDL clearance
8963889 Assembly of active LPL and LIPC lipase complexes
8964572 Lipid particle organization
1630316 Glycosaminoglycan metabolism
1638074 Keratan sulfate/keratin metabolism
1638091 Heparan sulfate/heparin (HS-GAG) metabolism
8978868 Fatty acid metabolism
8979227 Triglyceride metabolism
8981607 Intracellular oxygen transport
1663150 The activation of arylsulfatases
9006921 Integrin signaling
9006925 Intracellular signaling by second messengers
9006927 Signaling by Non-Receptor Tyrosine Kinases
9006936 Signaling by TGF-beta family members
9006931 Signaling by Nuclear Receptors
9006934 Signaling by Receptor Tyrosine Kinases
1793185 Chondroitin sulfate/dermatan sulfate metabolism
1799339 SRP-dependent cotranslational protein targeting to membrane
1810476 RIP-mediated NFkB activation via ZBP1
1834941 STING mediated induction of host immune responses
1834949 Cytosolic sensors of pathogen-associated DNA
881907 Gastrin-CREB signalling pathway via PKC and MAPK
917937 Iron uptake and transport
917977 Transferrin endocytosis and recycling
1971475 A tetrasaccharide linker sequence is required for GAG synthesis
947581 Molybdenum cofactor biosynthesis
964975 Vitamins B6 activation to pyridoxal phosphate
2022870 Chondroitin sulfate biosynthesis
2022857 Keratan sulfate degradation
2022854 Keratan sulfate biosynthesis
2022928 HS-GAG biosynthesis
2022923 Dermatan sulfate biosynthesis
2024101 CS/DS degradation
2024096 HS-GAG degradation
975634 Retinoid metabolism and transport
977347 Serine biosynthesis
5173105 O-linked glycosylation
5173214 O-glycosylation of TSR domain-containing proteins
5223345 Miscellaneous transport and binding events
3134975 Regulation of innate immune responses to cytosolic DNA
3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Details on Person D'Eustachio, Peter

_displayNameD'Eustachio, Peter
_timestamp2017-08-22 20:37:38
affiliation[Affiliation:69324] NYU School of Medicine, Department of Biochemistry
created[InstanceEdit:140933] D'Eustachio, P, 2004-08-24 19:39:07
crossReference[DatabaseIdentifier:5357569] ORCID:0000-0002-5494-626X
modified[InstanceEdit:76606] D'Eustachio, P, 2003-10-11 15:00:00
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:977488] D'Eustachio, P, 2010-10-19
[InstanceEdit:5209984] D'Eustachio, Peter, 2013-12-06
[InstanceEdit:5357570] D'Eustachio, Peter, 2014-03-24
[InstanceEdit:8932050] D'Eustachio, Peter, 2016-07-20
(author)[LiteratureReference:196997] Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth
[InstanceEdit:71738] D'Eustachio, Peter, 2003-04-14
[InstanceEdit:72811] D'Eustachio, P, 2003-06-12 00:00:00
[InstanceEdit:73154] D'Eustachio, P, 2003-06-12 18:05:00
[InstanceEdit:73172] D'Eustachio, P, 2003-06-13 13:48:00
[InstanceEdit:73259] D'Eustachio, P, 2003-06-13 15:14:00
[InstanceEdit:73307] D'Eustachio, P, 2003-06-13 16:04:00
[InstanceEdit:73408] D'Eustachio, P, 2003-06-15 00:00:00
[InstanceEdit:73440] D'Eustachio, P, 2003-06-16 00:00:00
[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
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