Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways authored by Rothfels, Karen (1226097)

DB_ID Name
3238698 WNT ligand biogenesis and trafficking
5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
5339716 Misspliced GSK3beta mutants stabilize beta-catenin
5339700 TCF7L2 mutants don't bind CTBP
5340573 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
5340588 RNF mutants show enhanced WNT signaling and proliferation
5358346 Hedgehog ligand biogenesis
5358351 Signaling by Hedgehog
5358747 S33 mutants of beta-catenin aren't phosphorylated
5358749 S37 mutants of beta-catenin aren't phosphorylated
5358751 S45 mutants of beta-catenin aren't phosphorylated
5358752 T41 mutants of beta-catenin aren't phosphorylated
5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
5362798 Release of Hh-Np from the secreting cell
5387390 Hh mutants abrogate ligand secretion
162582 Signal Transduction
1226099 Signaling by FGFR in disease
201681 TCF dependent signaling in response to WNT
201688 WNT mediated activation of DVL
201722 Formation of the beta-catenin:TCF transactivating complex
4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters
5467345 Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
5467348 Truncations of AMER1 destabilize the destruction complex
5467333 APC truncation mutants are not K63 polyubiquitinated
5467337 APC truncation mutants have impaired AXIN binding
5467343 Deletions in the AMER1 gene destabilize the destruction complex
5467340 AXIN missense mutants destabilize the destruction complex
1295596 Spry regulation of FGF signaling
1307965 betaKlotho-mediated ligand binding
5545619 XAV939 inhibits tankyrase, stabilizing AXIN
5610780 Degradation of GLI1 by the proteasome
5610783 Degradation of GLI2 by the proteasome
5610785 GLI3 is processed to GLI3R by the proteasome
5610787 Hedgehog 'off' state
5617833 Cilium Assembly
5620916 VxPx cargo-targeting to cilium
5620912 Anchoring of the basal body to the plasma membrane
5620924 Intraflagellar transport
5620920 Cargo trafficking to the periciliary membrane
5620922 BBSome-mediated cargo-targeting to cilium
5624138 Trafficking of myristoylated proteins to the cilium
5624958 ARL13B-mediated ciliary trafficking of INPP5E
5632684 Hedgehog 'on' state
5632681 Ligand-receptor interactions
5635838 Activation of SMO
5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription
5654726 Negative regulation of FGFR1 signaling
5654727 Negative regulation of FGFR2 signaling
5654732 Negative regulation of FGFR3 signaling
5654733 Negative regulation of FGFR4 signaling
5655253 Signaling by FGFR2 in disease
5655291 Signaling by FGFR4 in disease
5655302 Signaling by FGFR1 in disease
5655332 Signaling by FGFR3 in disease
4608870 Asymmetric localization of PCP proteins
5658034 HHAT G278V abrogates palmitoylation of Hh-Np
5658442 Regulation of RAS by GAPs
5658623 FGFRL1 modulation of FGFR1 signaling
5673000 RAF activation
5673001 RAF/MAP kinase cascade
5674135 MAP2K and MAPK activation
5674499 Negative feedback regulation of MAPK pathway
5675221 Negative regulation of MAPK pathway
5683057 MAPK family signaling cascades
5684996 MAPK1/MAPK3 signaling
5687128 MAPK6/MAPK4 signaling
4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
4641263 Regulation of FZD by ubiquitination
4641258 Degradation of DVL
4641257 Degradation of AXIN
4641265 Repression of WNT target genes
5694530 Cargo concentration in the ER
8851708 Signaling by FGFR2 IIIa TM
8853334 Signaling by FGFR3 fusions in cancer
8853333 Signaling by FGFR2 fusions
8853338 Signaling by FGFR3 point mutants in cancer
8853336 Signaling by plasma membrane FGFR1 fusions
8856828 Clathrin-mediated endocytosis
8856825 Cargo recognition for clathrin-mediated endocytosis
8856688 Golgi-to-ER retrograde transport
8873719 RAB geranylgeranylation
8876198 RAB GEFs exchange GTP for GDP on RABs
6802949 Signaling by RAS mutants
6802948 Signaling by high-kinase activity BRAF mutants
6802946 Signaling by moderate kinase activity BRAF mutants
6802957 Oncogenic MAPK signaling
6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
6802953 RAS signaling downstream of NF1 loss-of-function variants
6802952 Signaling by BRAF and RAF fusions
6803529 FGFR2 alternative splicing
6807878 COPI-mediated anterograde transport
6811438 Intra-Golgi traffic
6811436 COPI-independent Golgi-to-ER retrograde traffic
6811434 COPI-dependent Golgi-to-ER retrograde traffic
6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
6811440 Retrograde transport at the Trans-Golgi-Network
8951664 Neddylation
4791275 Signaling by WNT in cancer
9007101 Rab regulation of trafficking
9006921 Integrin signaling
9006925 Intracellular signaling by second messengers
9006927 Signaling by Non-Receptor Tyrosine Kinases
9006936 Signaling by TGF-beta family members
9006931 Signaling by Nuclear Receptors
9006934 Signaling by Receptor Tyrosine Kinases
3769402 Deactivation of the beta-catenin transactivating complex
3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
4839744 truncated APC mutants destabilize the destruction complex
4839748 AMER1 mutants destabilize the destruction complex
4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling
3858494 Beta-catenin independent WNT signaling
1839128 FGFR4 mutant receptor activation
1839130 Signaling by activated point mutants of FGFR3
1839124 FGFR1 mutant receptor activation
1839126 FGFR2 mutant receptor activation
1839120 Signaling by FGFR1 amplification mutants
1839122 Signaling by activated point mutants of FGFR1
1839117 Signaling by cytosolic FGFR1 fusion mutants
4086398 Ca2+ pathway
4086400 PCP/CE pathway
2023837 Signaling by FGFR2 amplification mutants
2033519 Activated point mutants of FGFR2
2033515 t(4;14) translocations of FGFR3
2033514 FGFR3 mutant receptor activation

Pathways reviewed by Rothfels, Karen (1226097)

DB_ID Name
3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Details on Person Rothfels, Karen

_displayNameRothfels, Karen
_timestamp2017-08-22 20:38:18
affiliation[Affiliation:1169271] Ontario Institute for Cancer Research
created[InstanceEdit:1226096] Rothfels, K, 2011-03-08
crossReference[DatabaseIdentifier:5357573] ORCID:0000-0002-0705-7048
modified[InstanceEdit:5357575] Rothfels, Karen, 2014-03-24
[InstanceEdit:8932050] D'Eustachio, Peter, 2016-07-20
(author)[InstanceEdit:163788] Bevan, AP, Charalambous, M, Gopinathrao, G, Joshi-Tope, G, Rothfels, Karen, Orlic-Milacic, Marija, 2005-05-06
[InstanceEdit:1226096] Rothfels, K, 2011-03-08
[InstanceEdit:1226104] Rothfels, K, 2011-03-08
[InstanceEdit:1226114] Rothfels, K, 2011-03-08
[InstanceEdit:1226878] Rothfels, K, 2011-03-09
[InstanceEdit:1226880] Rothfels, K, 2011-03-09
[InstanceEdit:1235109] Rothfels, K, 2011-03-23
[InstanceEdit:1268060] Rothfels, K, 2011-05-09
[InstanceEdit:1268070] Rothfels, K, 2011-05-09
[InstanceEdit:1268075] Rothfels, K, 2011-05-09
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