Reactome: A Curated Pathway Database

Query author contributions in Reactome

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Pathways authored by Orlic-Milacic, Marija (1169272)

DB_ID Name
2122947 NOTCH1 Intracellular Domain Regulates Transcription
2122948 Activated NOTCH1 Transmits Signal to the Nucleus
73884 Base Excision Repair
73893 DNA Damage Bypass
2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
2173789 TGF-beta receptor signaling activates SMADs
2173788 Downregulation of TGF-beta receptor signaling
2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
2197563 NOTCH2 intracellular domain regulates transcription
110314 Recognition of DNA damage by PCNA-containing replication complex
2219528 PI3K/AKT Signaling in Cancer
2219530 Constitutive Signaling by Aberrant PI3K in Cancer
3301854 Nuclear Pore Complex (NPC) Disassembly
3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer
3304347 Loss of Function of SMAD4 in Cancer
3304351 Signaling by TGF-beta Receptor Complex in Cancer
3304349 Loss of Function of SMAD2/3 in Cancer
162582 Signal Transduction
3311021 SMAD4 MH2 Domain Mutants in Cancer
3315487 SMAD2/3 MH2 Domain Mutants in Cancer
1227986 Signaling by ERBB2
1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
1236394 Signaling by ERBB4
195258 RHO GTPase Effectors
1250196 SHC1 events in ERBB2 signaling
1250342 PI3K events in ERBB4 signaling
1250347 SHC1 events in ERBB4 signaling
2299718 Condensation of Prophase Chromosomes
1251932 PLCG1 events in ERBB2 signaling
1251985 Nuclear signaling by ERBB4
1253288 Downregulation of ERBB4 signaling
4419969 Depolymerisation of the Nuclear Lamina
1306955 GRB7 events in ERBB2 signaling
1358803 Downregulation of ERBB2:ERBB3 signaling
1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
1362277 Transcription of E2F targets under negative control by DREAM complex
2465910 MASTL Facilitates Mitotic Progression
2467813 Separation of Sister Chromatids
2468052 Establishment of Sister Chromatid Cohesion
2470946 Cohesin Loading onto Chromatin
5625740 RHO GTPases activate PKNs
5625970 RHO GTPases activate KTN1
5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
5625900 RHO GTPases activate CIT
5626467 RHO GTPases activate IQGAPs
5627083 RHO GTPases regulate CFTR trafficking
5627123 RHO GTPases activate PAKs
5627117 RHO GTPases Activate ROCKs
5628897 TP53 Regulates Metabolic Genes
5633008 TP53 Regulates Transcription of Cell Death Genes
5633007 Regulation of TP53 Activity
5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer
5637812 Signaling by EGFRvIII in Cancer
5637810 Constitutive Signaling by EGFRvIII
5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer
5638303 Inhibition of Signaling by Overexpressed EGFR
2500257 Resolution of Sister Chromatid Cohesion
5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
5651801 PCNA-Dependent Long Patch Base Excision Repair
5655862 Translesion synthesis by POLK
5656169 Termination of translesion DNA synthesis
5656121 Translesion synthesis by POLI
2514853 Condensation of Prometaphase Chromosomes
5663220 RHO GTPases Activate Formins
5663213 RHO GTPases Activate WASPs and WAVEs
5666185 RHO GTPases Activate Rhotekin and Rhophilins
5668599 RHO GTPases Activate NADPH Oxidases
5674404 PTEN Loss of Function in Cancer
5674400 Constitutive Signaling by AKT1 E17K in Cancer
5685942 HDR through Homologous Recombination (HRR)
5685938 HDR through Single Strand Annealing (SSA)
5685939 HDR through MMEJ (alt-NHEJ)
5693532 DNA Double-Strand Break Repair
5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
5693538 Homology Directed Repair
5693537 Resolution of D-Loop Structures
5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
5693579 Homologous DNA Pairing and Strand Exchange
5693616 Presynaptic phase of homologous DNA pairing and strand exchange
5693606 DNA Double Strand Break Response
5693607 Processing of DNA double-strand break ends
5696400 Dual Incision in GG-NER
5696398 Nucleotide Excision Repair
5696399 Global Genome Nucleotide Excision Repair (GG-NER)
5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
5696394 DNA Damage Recognition in GG-NER
5696395 Formation of Incision Complex in GG-NER
8847453 Synthesis of PIPs in the nucleus
8848021 Signaling by PTK6
8847993 ERBB2 Activates PTK6 Signaling
8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
8849470 PTK6 Regulates Cell Cycle
8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
8849468 PTK6 Regulates Proteins Involved in RNA Processing
8849474 PTK6 Activates STAT3
8849473 PTK6 Expression
8849472 PTK6 Down-Regulation
8850843 Phosphate bond hydrolysis by NTPDase proteins
2559586 DNA Damage/Telomere Stress Induced Senescence
2559585 Oncogene Induced Senescence
2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
2559583 Cellular Senescence
2559582 Senescence-Associated Secretory Phenotype (SASP)
2559580 Oxidative Stress Induced Senescence
8851907 MET activates PI3K/AKT signaling
8851805 MET activates RAS signaling
8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
2562597 Optineurin and Myosin Phosphatase Negatively Regulate PLK1
8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
8854518 AURKA Activation by TPX2
8854521 Interaction between PHLDA1 and AURKA
2565942 Regulation of PLK1 Activity at G2/M Transition
8857538 PTK6 promotes HIF1A stabilization
8863678 Neurodegenerative Diseases
8863795 Downregulation of ERBB2 signaling
8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
8865999 MET activates PTPN11
8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
8866907 Activation of the TFAP2 (AP-2) family of transcription factors
8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors
8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
8874081 MET activates PTK2 signaling
8875513 MET interacts with TNS proteins
8875360 InlB-mediated entry of Listeria monocytogenes into host cell
8875656 MET receptor recycling
8875555 MET activates RAP1 and RAC1
8875791 MET activates STAT3
8875878 MET promotes cell motility
8876493 InlA-mediated entry of Listeria monocytogenes into host cells
8876384 Listeria monocytogenes entry into host cells
8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
1538133 G0 and Early G1
8878159 Transcriptional regulation by RUNX3
8878166 Transcriptional regulation by RUNX2
8878171 Transcriptional regulation by RUNX1
6781823 Formation of TC-NER Pre-Incision Complex
6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
6782135 Dual incision in TC-NER
6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
6783310 Fanconi Anemia Pathway
6785631 ERBB2 Regulates Cell Motility
3642279 TGFBR2 MSI Frameshift Mutants in Cancer
3642278 Loss of Function of TGFBR2 in Cancer
6791312 TP53 Regulates Transcription of Cell Cycle Genes
3645790 TGFBR2 Kinase Domain Mutants in Cancer
6796648 TP53 Regulates Transcription of DNA Repair Genes
3656535 TGFBR1 LBD Mutants in Cancer
3656534 Loss of Function of TGFBR1 in Cancer
3656532 TGFBR1 KD Mutants in Cancer
6803207 TP53 Regulates Transcription of Caspase Activators and Caspases
6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
6803211 TP53 Regulates Transcription of Death Receptors and Ligands
6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
6804759 Regulation of TP53 Activity through Association with Co-factors
6804758 Regulation of TP53 Activity through Acetylation
6804757 Regulation of TP53 Degradation
6804756 Regulation of TP53 Activity through Phosphorylation
6804754 Regulation of TP53 Expression
6804760 Regulation of TP53 Activity through Methylation
6806003 Regulation of TP53 Expression and Degradation
6806834 Signaling by MET
6807004 Negative regulation of MET activity
6806942 MET Receptor Activation
6807070 PTEN Regulation
6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
6811555 PI5P Regulates TP53 Acetylation
6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
8931987 RUNX1 regulates estrogen receptor mediated transcription
8934593 Regulation of RUNX1 Expression and Activity
2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
2644603 Signaling by NOTCH1 in Cancer
2644605 FBXW7 Mutants and NOTCH1 in Cancer
2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
8935964 RUNX1 regulates expression of components of tight junctions
8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
8939245 RUNX1 regulates transcription of genes involved in BCR signaling
8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
8939256 RUNX1 regulates transcription of genes involved in WNT signaling
8939902 Regulation of RUNX2 expression and activity
8940973 RUNX2 regulates osteoblast differentiation
8941284 RUNX2 regulates chondrocyte maturation
8941326 RUNX2 regulates bone development
8941332 RUNX2 regulates genes involved in cell migration
8941333 RUNX2 regulates genes involved in differentiation of myeloid cells
8941855 RUNX3 regulates CDKN1A transcription
8941856 RUNX3 regulates NOTCH signaling
8941858 Regulation of RUNX3 expression and activity
3700989 Transcriptional Regulation by TP53
8943723 Regulation of PTEN mRNA translation
8943724 Regulation of PTEN gene transcription
8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation
8948747 Regulation of PTEN localization
8948751 Regulation of PTEN stability and activity
8949275 RUNX3 Regulates Immune Response and Cell Migration
8951430 RUNX3 regulates WNT signaling
8951671 RUNX3 regulates YAP1-mediated transcription
8951936 RUNX3 regulates p14-ARF
8951911 RUNX3 regulates RUNX1-mediated transcription
8952158 RUNX3 regulates BCL2L11 (BIM) transcription
2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
8953750 Transcriptional Regulation by E2F6
2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants
2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer
1643713 Signaling by EGFR in Cancer
8985586 SLIT2:ROBO1 increases RHOA activity
8985801 Regulation of cortical dendrite branching
9010642 ROBO receptors bind AKAP5
9010553 Regulation of expression of SLITs and ROBOs
2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
1912408 Pre-NOTCH Transcription and Translation
1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum
1912422 Pre-NOTCH Expression and Processing
2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus
2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
2980766 Nuclear Envelope Breakdown
2993913 Clearance of Nuclear Envelope Membranes from Chromatin
2995383 Initiation of Nuclear Envelope Reformation
2995410 Nuclear Envelope Reassembly
1963640 GRB2 events in ERBB2 signaling
1963642 PI3K events in ERBB2 signaling
1980143 Signaling by NOTCH1

Details on Person Orlic-Milacic, Marija

_displayNameOrlic-Milacic, Marija
_timestamp2017-08-22 20:37:34
affiliation[Affiliation:1169271] Ontario Institute for Cancer Research
created[InstanceEdit:1169273] Orlic-Milacic, Marija, 2011-01-18
crossReference[DatabaseIdentifier:5357984] ORCID:0000-0002-3218-5631
modified[InstanceEdit:1604767] Orlic-Milacic, M, 2011-09-19
[InstanceEdit:5357986] Rothfels, Karen, 2014-03-27
[InstanceEdit:8932050] D'Eustachio, Peter, 2016-07-20
(author)[InstanceEdit:163788] Bevan, AP, Charalambous, M, Gopinathrao, G, Joshi-Tope, G, Rothfels, Karen, Orlic-Milacic, Marija, 2005-05-06
[InstanceEdit:1169273] Orlic-Milacic, Marija, 2011-01-18
[InstanceEdit:1169413] Orlic-Milacic, Marija, 2011-01-18
[InstanceEdit:1169427] Orlic-Milacic, Marija, 2011-01-18
[InstanceEdit:1169430] Orlic-Milacic, Marija, 2011-01-18
[InstanceEdit:1169436] Orlic-Milacic, Marija, 2011-01-18
[InstanceEdit:1169627] Orlic-Milacic, Marija, 2011-01-19
[InstanceEdit:1173208] Orlic-Milacic, Marija, 2011-01-21
[InstanceEdit:1173213] Orlic-Milacic, Marija, 2011-01-21
[InstanceEdit:1173214] Orlic-Milacic, Marija, 2011-01-21
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