New and Updated Pathways. In version V62, topics with new or revised pathways include Developmental biology (Signaling by Robo receptor), Gene expression (Transcriptional regulation by E2F6 and Transcriptional regulation by RUNX2), and Immune System (Interleukin-7 family signaling, Interleukin-15 family signaling, Interleukin-35 family signaling, and Interleukin-38 family signaling).
Illustrations are now available for Aquaporin-mediated transport, Cellular senescence, Epigenetic regulation of gene expression, Gene Expression, Negative epigenetic regulation of rRNA expression, O2/CO2 exchange in erythrocytes, Peptide hormone metabolism, Positive epigenetic regulation of rRNA expression, Post-translational protein modification, Response to metal ions, Signal Transduction, and SLC-mediated transmembrane transport.
Eight Drosophila signaling pathways, Hedgehog, Hippo/Warts, lmd, insulin receptor, JAK/STAT, planar cell polarity, Toll, and Wingless, as well as our representation of the Nobel Prize-winning circadian clock pathway, all manually curated in collaboration with FlyBase, are included in this release.
Thanks to our Contributors. Patricia Ducy is our external author. Patricia Ducy, Jorg Goronzy, Anna Herlihy, Alexander Jaworski, Umesh Kumar, Javier Francisco Mora, Manoj Patidar, Yuliya Pylayeva-Gupta, Kailash Singh, and Ren Sun are our external reviewers.
Annotation Statistics. Reactome comprises 11,302 human reactions organized into 2,176 pathways involving 10,878 proteins encoded by 10,712 different human genes, 1,768 small molecules, and 11,284 complexes. These annotations are supported by 27,526 literature references. We have projected these reactions onto 121,709 orthologous proteins, creating 20,854 orthologous pathways in 18 non-human species. Version 62 has annotations for 1,334 protein variants (mutated proteins) and their post-translationally modified forms, derived from 285 proteins. These have been used to annotate 506 disease-specific complexes and 906 disease-specific reactions organized into 453 pathways and subpathways, and tagged with 294 Disease Ontology terms.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website.
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